血清降钙素和C-反应蛋白联合检测在新生儿感染性疾病诊断中的价值分析

Analysis of PCT and CRP combined detection in the diagnosis of neonatal infectious diseases

目的研究降钙素(PCT)和C反应蛋白(CRP)联合检测在新生儿感染性疾病诊断中的价值。方法研究对象选取我院2016年3月~2017年4月收治的确诊有感染性疾病新生儿44例(观察组)及正常新生儿44例(对照组),于治疗前采集感染性疾病患儿3 ml静脉血,对照组在出生后7 d内采集静脉血3 ml,检测两组PCT、CRP;取观察组患儿治疗前及治疗后10 d的静脉血,检测PCT、CRP、中性粒细胞(NEUT)含量,使用Spearman秩相关系数检验PCT、CRP与NEUT含量的相关性。结果两组PCT、CRP血清浓度比较,观察组均显著高于对照组(P<0.05),观察组PCT及CRP阳性率显著高于对照组(P<0.05)。治疗后,观察组患儿PCT、CRP与NEUT含量与治疗前比较,均显著降低,差异均有统计学意义(P<0.05),PCT、CRP与NEUT两两间做基于Spearman秩相关系数显示,PCT、CRP与NEUT两两间比较均成正相关(P<0.05)。结论 PCT和CRP对新生儿感染性疾病的早期诊断,判断感染程度,确定治疗效果有重要价值,应在临床推广使用。

Objective To study the value of combined detection of calcitonin（PCT） and C-reactive protein（CRP） in the diagnosis of neonatal infectious diseases.Methods Participants 44 newborns（observation group） and 44 normal newborns（control group） admitted to our hospital from March 2016 to April 2017 were enrolled in this study.Infections were collected before treatment 3 ml venous in children with disease and 3 ml venous blood in control group within 7 days after birth.PCT and CRP were measured in two groups.Venous blood before treatment and 10 days after treatment were collected in the observation group,CRP,neutrophil（NEUT） content,using Spearman rank correlation coefficient test PCT,CRP NEUT content correlation.Results The serum levels of PCT and CRP in the two groups were significantly higher than those in the control group（P〈0.05）.The positive rate of PCT and CRP in the observation group was significantly higher than that in the control group（P〈0.05）.The levels of PCT,CRP and NEUT in the observation group were significantly lower than those before treatment,the differences were statistically significant（P〈0.05）.The results of PCT,CRP and NEUT were based on the Spearman rank correlation coefficient.The results showed that PCT,CRP and NEUT were related（P〈0.05）.Conclusion PCT and CRP haveimportant value in the early diagnosis of neonatal infectious diseases,determine the degree of infection,and determine the therapeutic effect,and apply them to clinical practice.