喜炎平注射液辅助改善肺炎支原体肺炎患儿免疫功能的研究

Assistance of Xiyanping injection in improving immunological function of children with mycoplasma pneumonia

目的观察喜炎平注射液辅助阿奇霉素治疗对肺炎支原体肺炎(MPP)患儿免疫功能的影响。方法选取2014年1月至2016年10月朝阳市第二医院儿科门诊收治的MPP患儿60例,随机分为观察组和对照组各30例。对照组应用静脉滴注阿奇霉素治疗,观察组在对照组治疗基础上加用喜炎平注射液静脉滴注。7d为1个疗程,连续治疗2个疗程。观察两组临床疗效、细胞免疫功能(CD4^+、CD8^+水平)及体液免疫功能(IgA、IgG、IgM水平)。结果观察组患儿总有效率为90.0%(27/30),显著高于对照组66.7%(20/30),差异有统计学意义(P<0.05)。治疗后两组CD4^+水平以及CD4^+/CD8^+值均显著高于治疗前,CD8^+水平显著低于治疗前,差异有统计学意义(P<0.05);治疗后观察组CD4^+水平以及CD4^+/CD8^+值显著高于对照组,而CD8^+水平显著低于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿血清IgM、IgA水平显著低于治疗前,而IgG水平高于治疗前,差异有统计学意义(P<0.05)。治疗后观察组血清IgM、IgA、IgG水平均显著低于对照组,差异有统计学意义(P<0.05)。结论相较于单独应用阿奇霉素,喜炎平可辅助性地从细胞免疫和体液免疫两方面增强MPP患儿的机体免疫功能,提高临床疗效。

Objective To investigate the effects of combined treatment with azithromycin and Xiyanping injection on immunological function of children with mycoplasma pneumonia.Methods Sixty children with mycoplasma pneumonia were included and equally randomized into treatment group and control group（30 in each group）.Children in the control group received intravenous administration of azithromycin,and those in the treatment group received intravenous administration of azithromycin combined with Xiyanping injection.The treatment lasted for 2 courses,with 7 days in one course.The treatment efficacy was observed.The CD4^＋and CD8^＋levels as well as IgA,IgG and IgM levels were also observed.Results The total effective rate in the treatment group was significantly higher than that in the control group（90%vs 67%,P〈0.05）.Serum CD4^＋level and the ratio of CD4^＋/CD8^＋were significantly increased,while serum CD8^＋level was significantly decreased in both groups after treatment compared with before treatment（P〈0.05）.Serum CD4^＋level and the ratio of CD4^＋/CD8^＋were significantly increased,while serum CD8^＋level was significantly decreased in the treatment group compared with the control group（P〈0.05）.After treatment,serum levels of IgM and IgA were significantly decreased,while the serum level of IgG was significantly increased in both groups（P〈0.05）.Serum levels of IgM,IgA and IgG were significantly decreased in the treatment group compared with the control group（P〈0.05）.Conclusion Xiyanping injection can assist azithromycin in improving immunological function of children with mycoplasma pneumonia,thereby enhancing the treatment efficacy.