亲属活体供肾肾体积与受体体表面积比值对早期移植肾功能的影响

Effect of the ratio of living related donor renal volume to recipient body surface area on early function of transplanted kidney

目的探讨亲属活体供肾肾体积(RV)与受体体表面积(BSA)比值(RV/BSA)与术后早期移植肾功能的关系。方法回顾性分析行亲属活体肾移植术的120对供、受体的临床资料。根据RV/BSA将受体分为A组(RV/BSA<65.33 m L/m2),B组(RV/BSA为65.33~76.49 m L/m2),C组(RV/BSA为76.50~96.96 m L/m2),D组(RV/BSA>96.96 m L/m2)。比较4组受体术后估算肾小球滤过率(e GFR),分析RV/BSA与受体术后6、12个月e GFR的相关性。结果 A组术后6个月e GFR明显低于B组、C组和D组(t=2.313,2.947,5.903;均为P<0.05)。A组术后12个月e GFR亦明显低于B组、C组和D组(t=2.189,2.433,2.909;均为P<0.05)。RV/BSA与受体术后6、12个月的e GFR均存在相关性(均为P<0.05)。结论 RV/BSA与亲属活体肾移植术后早期移植肾功能密切相关。

Objective To investigate the relationship between the ratio of living related donor renal volume（RV） to recipient body surface area（BSA）（RV/BSA） and early postoperative function of transplanted kidney. Methods Clinical data of 120 pairs of donors and recipients undergoing living related renal transplantation were retrospectively analyzed. According to the RV/BSA ratio, the recipients were divided into group A（RV/BSA65.33 m L/m2）, group B（RV/BSA 65.33~76.49 m L/m2）, group C（RV/BSA 76.50~96.96 m L/m2） and group D（RV/BSA 96.96 m L/m2）. The postoperative estimated glomerular filtration rate（e GFR） of recipients was compared among 4 groups. The correlation between the RV/BSA and e GFR of recipients at postoperative 6 and 12 months was analyzed. Results The e GFR at postoperative 6 month in group A was significantly lower than that in groups B, C and D（t=2.313, 2.947, 5.903; all P〈0.05）. The e GFR at postoperative 12 month in group A was also significantly lower than that in groups B, C and D（t=2.189, 2.433, 2.909; all P〈0.05）. The RV/BSA was significantly correlated with the e GFR of recipients at postoperative 6 and 12 months（all P〈0.05）. Conclusions RV/BSA is intimately correlated with the early function of transplanted kidney after living related renal transplantation.