血浆脂蛋白a与冠状动脉Gensini积分的相关性

Correlation analysis of plasma concentration of lipoprotein(a)and coronary Gensini score

目的通过分析不同冠状动脉(冠脉)狭窄程度患者冠脉Gensini积分及血浆脂蛋白a[lipoprotein(a),Lp(a)]的相关性,了解Lp(a)与冠脉病变程度的关系。方法将180例非急性冠脉综合征择期行冠脉造影的患者,根据冠脉造影结果分成非冠状动脉粥样硬化性心脏病(冠心病)组(对照组),单支病变组,二支病变组,三支和(或)主干病变组。多组间两两血浆Lp(a)浓度及Gensini积分比较采用LSD-t检验进行分析;Lp(a)与Gensini积分的相关性分析选用spearman秩相关进行分析。结果4组间Lp(a)浓度比较,差异无统计学意义(P>0.05),仅三支组和(或)主干病变组Lp(a)浓度与Gensini积分有弱相关性(Sr=0.281,P=0.042)。结论在严重冠脉病变患者中Lp(a)浓度与冠脉病变程度呈正相关关系。

Objectives To explore the correlation between lipoprotein（a）[Lp（a）]and Gensini score of patients with coronary artery disease.MethodsTotally 180 patients with chest pain and without acute coronary syndrome（ACS）were enrolled in this study.All the cases underwent coronary angiography.The extent of coronary artery disease was assessed by Gensini score system.The subjects were divided into 4 groups according to coronary angiography：normal group,single lesion group,two lesions group,three lesions and（or）left main lesion group.Comparison of plasma concentration of Lp（a）among the 4 groups was analyzed by LSD-t test.Correlation analysis of plasma concentration of LP（a）and coronary Gensini score was analyzed by spearman rank correlation.ResultsPlasma concentration of LP（a）had no obviously differences among the 4 groups（P〉0.05）.Plasma concentration of LP（a）and Gensini score have a weak correlation only in the three lesions and（or）left main lesion group（Sr=0.281,P=0.042）.ConclusionsIn patients with severe coronary artery lesions,plasma concentration of LP（a）and degree of the coronary artery lesions have a positive correlation.