摘要
BACKGROUND: This study was done to compare the admission Full Outline of Unresponsiveness(FOUR) score and Glasgow Coma Scale(GCS) as predictors of outcome in children with impaired consciousness.METHODS: In this observational study, children(5–12 years) with impaired consciousness of <7 days were included. Children with traumatic brain injury, on sedatives or neuromuscular blockade; with pre-existing cerebral palsy, mental retardation, degenerative brain disease, vision/hearing impairment; and seizure within last 1 hour were excluded. Primary outcomes: comparison of area under curve(AUC) of receiver operating characteristic(ROC) curve for in-hospital mortality. Secondary outcomes: comparison of AUC of ROC curve for mortality and poor outcome on Pediatric Overall Performance Category Scale at 3 months.RESULTS: Of the 63 children, 20 died during hospital stay. AUC for in-hospital mortality for GCS was 0.83(CI 0.7 to 0.9) and FOUR score was 0.8(CI 0.7 to 0.9) [difference between areas –0.0250(95%CI 0.0192 to 0.0692), Z statistic 1.109, P=0.2674]. AUC for mortality at 3 months for GCS was 0.78(CI 0.67 to 0.90) and FOUR score was 0.74(CI 0.62 to 0.87)(P=0.1102) and AUC for poor functional outcome for GCS was 0.82(CI 0.72 to 0.93) and FOUR score was 0.79(CI 0.68 to 0.9)(P=0.2377), which were also comparable. Inter-rater reliability for GCS was 0.96 and for FOUR score 0.98.CONCLUSION: FOUR score was as good as GCS in prediction of in-hospital and 3-month mortality and functional outcome at 3 months. FOUR score had a good inter-rater reliability.
BACKGROUND： This study was done to compare the admission Full Outline of Unresponsiveness （FOUR） score and Glasgow Coma Scale （GCS） as predictors of outcome in children with impaired consciousness. METHODS： In this observational study, children （5-12 years） with impaired consciousness of 〈7 days were included. Children with traumatic brain injury, on sedatives or neuromuscular blockade; with pre-existing cerebral palsy, mental retardation, degenerative brain disease, vision/ hearing impairment; and seizure within last 1 hour were excluded. Primary outcomes： comparison of area under curve （AUC） of receiver operating characteristic （ROC） curve for in-hospital mortality. Secondary outcomes： comparison of AUC of ROC curve for mortality and poor outcome on Pediatric Overall Performance Category Scale at 3 months. RESULTS： Of the 63 children, 20 died during hospital stay. AUC for in-hospital mortality for GCS was 0.83 （CI 0.7 to 0.9） and FOUR score was 0.8 （CI 0.7 to 0.9） [difference between areas -0.0250 （95%C/0.0192 to 0.0692）, Z statistic 1.109, P=0.2674]. AUC for mortality at 3 months for GCS was 0.78 （CI 0.67 to 0.90） and FOUR score was 0.74 （CI 0.62 to 0.87） （P=0.1102） and AUC for poor functional outcome for GCS was 0.82 （CI 0.72 to 0.93） and FOUR score was 0.79 （CI 0.68 to 0.9） （P=0.2377）, which were also comparable. Inter-rater reliability for GCS was 0.96 and for FOUR score 0.98. CONCLUSION： FOUR score was as good as GCS mortality and functional outcome at 3 months. FOUR score n prediction of in-hospital and 3-month had a good inter-rater reliability.
