CA19-9、CA125和CEA联合检测在AFP阴性的ICC鉴别诊断中的效果

Effect of Combined Detection of CA19-9 and CA125 and CEA in Differential Diagnosis of AFP Negative ICC

目的:探究CA19-9(血清癌抗原19-9)、CA125(癌抗原125)和CEA(癌胚抗原)联合检测在AFP(甲胎蛋白)阴性的ICC(肝内胆管细胞癌)鉴别诊断中的效果。方法:收集某院2015年12月~2017年12月收治的92例ICC患者,根据AFP的阳阴性,分甲组(阴性组n=46)和乙组(阳性组n=46)。用微粒子酶联免疫分析法对CEA、CA125、CA19-9进行检测,比较血清肿瘤标记物及其诊断效能。结果:与乙组CEA、CA125、CA19-9水平比较,甲组较高,具有统计学差异,P<0.05;根据CEA、CA125、CA19-9截断点可知CEA的正确率、特异度、灵敏度分别是60.9%、65.2%、59.2%;CA125的分别是65.2%、69.6%、56.5%,CA19-9的分别是68.5%、76.1%、60.9%。结论:AFP阴性的ICC患者进行CEA、CA125、CA19-9检测,可有效提高ICC患者的诊断准确率,效果确切,值得借鉴。

Objective：To explore the effect of combined detection of CA19-9 and CA125 and CEA in differential diagnosis of AFP negative ICC.Methods：92 cases of ICC patients treated in a hospital from December 2015 to December 2017 were collected and divided into the group A（negative group,n=46）and group B（positive group,n=46）according to AFP.The CEA,CA125 and CA19-9 were tested with microparticle enzyme-linked immunoassay,and the serum tumor markers and their diagnostic efficacy were compared.Results：The level of levels of CEA,CA125 and CA19-9 in group A were higher than those in group B,with statistical difference（P〈0.05）.According to the cut-off points of CEA,CA125 and ca19-9,the accuracy,specificity and sensitivity of CEA was 60.9%,65.2%and 59.2%respectively.The accuracy,specificity and sensitivity was 65.2%,69.6% and 56.5% respectively,while the accuracy,specificity and sensitivity was68.5%,76.1%and 60.9%respectively.Conclusion：The detection of CEA,CA125 and ca19-9 in the ICC patients with AFP negative can effectively improve the diagnostic accuracy of ICC patients,which the effect is exact and worth learning.