高强度间歇运动对T2DM患者血糖控制、脂肪细胞因子分泌、氧化应激反应的影响

Effect of high-intensity interval training on blood glucose control,adipocytokine secretion and oxidative stress response in patients with T2DM

目的:探讨高强度间歇运动对T2DM患者血糖控制、脂肪细胞因子分泌、氧化应激反应的影响。方法:选择在本院进行治疗的首诊T2DM患者92例,随机分为对照组、高强度间歇运动组各46例。对照组接受常规降糖治疗,高强度间歇运动组接受降糖联合高强度间歇运动,持续干预3月。对比两组干预前后血糖控制、脂肪细胞因子分泌、氧化应激反应的差异。结果:干预前,两组外周血中血糖指标水平,血清中脂肪细胞因子及氧化应激指标含量的差异无统计学意义。干预3月后,高强度间歇运动组患者外周血中血糖指标FPG、FINS、2hPBG的水平低于对照组;血清中脂肪细胞因子APN的含量高于对照组,LEP、Resistin、CHEM的含量低于对照组;血清中氧化应激指标MDA、ROS的含量低于对照组,T-AOC的含量高于对照组。结论:首诊T2DM患者在常规降糖治疗同时进行高强度间歇运动干预,可进一步控制患者血糖水平并调节机体脂肪细胞因子分泌、减轻全身氧化应激反应。

Objective：To investigate the effect of high-intensity interval training on blood glucose control,adipocytokine secretion and oxidative stress response in patients with T2 DM.Methods：92 patients with newly diagnosed T2 DM who were treated in this hospital between July 2016 and July 2017 were divided into the control group（n=46）and HIIT group（n=46）by random number table method.Control group received conventional hypoglycemic therapy,HIIT group received hypoglycemic combined with high-intensity interval training therapy,and the intervention lasted for 3 months.The differences in blood glucose control,adipocytokine secretion and oxidative stress response were compared between the two groups before and after intervention.Results：Before intervention,the differences in blood glucose index levels in peripheral blood as well as the contents of adipocytokines and oxidative stress indexes in serum were not statistically significant between the two groups of patients.After 3 months of intervention,blood glucose indexes FPG,FINS and 2 hPBG levels in peripheral blood of HIIT group were lower than those of control group;adipocytokine APN content in serum was higher than that of control group whereas LEP,Resistin and CHEM contents were lower than those of control group;oxidative stress indexes MDA and ROS contents in serum were lower than those of control group whereas T-AOC content was higher than that of control group.Conclusion：Routine hypoglycemic therapy combined with high-intensity interval training can further control the blood glucose levels,regulate the secretion of adipocytokines and reduce the systemic oxidative stress response.