后循环脑梗死患者血清中血小板活化因子含量与炎症反应指标及血脂代谢的相关性

The correlation of serum platelet activating factor level with inflammatory response indexes and blood lipid metabolism in patients with posterior circulation cerebral infarction

目的:研究后循环脑梗死患者血清中血小板活化因子(PAF)含量与炎症反应指标及血脂代谢的相关性。方法:选择在佛山市第二人民医院神经内科病房住院诊断为后循环脑梗死的患者作为研究的脑梗死组,同期体检的健康者作为对照组。采集血清并测定PAF、炎症反应指标、脂代谢指标的含量。结果:脑梗死组患者血清中PAF、HMGB1、FKN、CD40L、IL-18、HCY、DKK1、LDL-C、Vaspin、Resistin的含量显著高于对照组,Visfatin的含量显著低于对照组;脑梗死组中高PAF含量患者血清中HMGB1、FKN、CD40L、IL-18、HCY、DKK1、LDL-C、Vaspin、Resistin的含量显著高于低PAF含量患者,Visfatin的含量显著低于低PAF含量患者。结论:后循环脑梗死患者血清中PAF含量升高与炎症反应激活、脂代谢紊乱密切相关。

Objective：To study the correlation of serum platelet activating factor（PAF）level with inflammatory response indexes and blood lipid metabolism in patients with posterior circulation cerebral infarction.Methods：Patients who were diagnosed with posterior circulation cerebral infarction in Neurology Department of the Second People’s Hospital of Foshan City between October 2016 and October 2017 were selected as the cerebral infarction group of the research,and healthy volunteers who received physical examination in the hospital during the same period were selected as control group.Serum was collected to determine the contents of PAF,inflammatory response indexes and lipid metabolism indexes.Results：Serum PAF,HMGB1,FKN,CD40 L,IL-18,HCY,DKK1,LDL-C,Vaspin and Resistin levels of cerebral infarction group were greatly higher than those of control group whereas Visfatin level was greatly lower than that of control group;serum HMGB1,FKN,CD40 L,IL-18,HCY,DKK1,LDL-C,Vaspin and Resistin levels of cerebral infarction group of patients with high PAF level were greatly higher than those of patients with low PAF level whereas Visfatin level was greatly lower than that of patients with low PAF level.Conclusion：The increase of PAF content in serum of patients with posterior circulation cerebral infarction is closely related to the inflammatory response activation and lipid metabolism disorder.