强化阿托伐他汀治疗对急性脑梗死患者血清sdLDL水平影响分析

Effects of intensive statin therapy on serum sdLDL levels in patients with acute cerebral infarction

目的:研究强化阿托伐他汀钙(AC)治疗对急性脑梗死(ACI)临床效果及血清低密度脂蛋白(sd LDL)水平的影响。方法:选取2015年12月~2016年12月我院收治的102例ACI患者作为观察对象。以随机数字表法分为对照组和观察组各51例。两组均采用常规ACI治疗,对照组在常规治疗的同时给予正常剂量的AC(20mg/d)治疗;观察组在接受常规治疗的同时给予强化剂量的AC(40mg/d)治疗。对比治疗前后的疗效及高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)等各项指标变化情况。结果:治疗后,观察组治愈占比45.10%(23/51),总有效率94.12%(48/51),显著高于对照组的23.53%(12/51)、78.43%(40/51);治疗后观察组血脂与炎症因子均显著低于对照组;治疗前两组颈动脉内膜中层厚度(IMT)及斑块面积均无显著差异,治疗后两组IMT及斑块面积均显著下降,观察组下降幅度明显大于对照组;治疗前两组sd LDL水平均无显著差异,治疗后1个月后及6个月观察组与对照组sd LDL水平均显著下降,观察组下降幅度明显大于对照组(P<0.05)。结论:强化AC治疗ACI不仅疗效显著,还可以有效降低血脂与炎症因子指标,同时有效改善IMT值及斑块面积,sd LDL水平大幅度下降,值得临床推广。

Objective： To study the effect of AC therapy on the clinical efficacy and serum sdLDL level in patients with ACL Methods： Chose December 2015 to December 2016 to 102 ACI patients treated in our hospital as the research object. In digital method randomly divided into control group （51 cases） and observation group（51 cases）. Two patients were treated with ACI therapy, patients in control group received conventional treatment at the same time is given often the close of AC （20rag/d） treatment; patients in observation group received routine treatment given intensive dose of AC （ibid.） （40mg/d）. The treatment and curative effect of HDL-C before and after treatment were compared between two groups. The changes of the indicators such as LDL-C. Results： After treatment in observation group were cured accounted for 45.10%（23/51）, the total efficiency of 94.12% （48/51）, significantly higher than the control group 23.53% （12/51）, 78.43% （40/51）（P〈0.05）; after treatment, observation group clinical blood ]ipids and inflammatory factors were significantly lower than the control group （P〈0.05）; two groups of patients before treatment of 1MT and plaque area were not significant the difference after treatment, the observation group and the control group of IMT and plaque area were significantly decreased, and the observation group decreased more significantly than the control group （P〈0.05）; patients before treatment, sdLDL levels of the two groups were no significant difference after treatment after 1 months and 6 months after the observation group and the control group sdLDL levels were significantly decreased, and the observation group the decline was significantly higher than the control group （P〈 0.05）. Conclusion： Strengthen the AC in the treatment of ACI curative effect has obvious curative effect, can effectively reduce the blood lipid and inflammatory factor index, and improve the value of IMT and plaque area, sdLDL levels have been greatly reduced in the treatment, which is worthy of clinical application.