马来酸依那普利叶酸片用于轻、中度高血压患者降压和降低同型半胱氨酸的疗效及安全性

The efficacy and safety of ionopril folic acid in maleic acid in patients with mild to moderate hypertension and reduced homocysteine

目的:探讨马来酸依那普利叶酸片对轻、中度高血压的降压及降低同型半胱氨酸(Hcy)的临床疗效及安全性。方法:选取2016年1月~2017年3月本院134例轻、中度高血压患者,按治疗方案的不同平分为研究组、常规组,各67例。对研究组给予马来酸依那普利叶酸片进行干预,常规组则给予依那普利片进行干预,并将两组临床总有效率、不良反应发生率、舒张压、收缩压及血浆Hcy水平等相关指标进行对比。结果:研究组临床总有效率为97.01%,明显高于常规组的85.07%(X^2=8.739、P=0.003),组间对比具有显著差异;研究组与常规组在用药后不良反应发生率上对比具有显著差异(X^2=10.586、P=0.001);研究组与常规组在舒张压、收缩压及Hcy水平等相关指标上对比差异具有统计学意义(t=-5.726、P=0.000,t=-4.573、P=0.000,t=-9.005、P=0.000)。结论:相比依那普利片,马来酸依那普利叶酸片对轻、中度高血压的降压效果更好,还可有效降低Hcy水平,维持血压稳定性,且无明显毒副作用,用药安全性较高,具备临床意义与运用价值。

objective： to investigate the clinical efficacy and safety of ionopril folic acid tablets in patients with mild and moderate hypertension, and to reduce the clinical efficacy and safety of homocysteine （Hcy）. Methods： 134 cases of mild and moderate hypertension were selected from the hospital in 2016.1-2017.3. On the team with enalaprilat folic acid, maleic acid to intervene, conventional group give enalaprilat intervention, and two groups of clinical total effective rate, incidence of adverse reactions, diastolic blood pressure and systolic blood pressure and plasma Hcy levels and other related indicators were compared. Results the total clinical efficiency of the patients was 97.01%, significantly higher than 85.07% of the conventional group （X2=8.739,P=0.003）, and the comparison between groups was statistically significant. Compared with the normal group, the incidence of adverse reactions was statistically significant （X2=10.586,P=0.001）. The comparison between the study group and the conventional group on the diastolic pressure, systolic blood pressure and Hcy level was statistically significant （t=-5.726, P=0.000, t=-4.573, P=0.000, t=-9.005, P=0.000）. Conclusion compared with enalaprilat, maleic acid enalaprilat folic acid tablets in patients with mild and moderate hypertension antihypertensive effect is better, also can effectively reduce the level of Hcy, maintaining patients＇ blood pressure stability, and no obvious side effects, drug safety is higher, has clinical significance and application value.