血清Klotho蛋白与高血压的关系

The relationship between serum Klotho protein and hypertension

目的检验血清Klotho蛋白水平与高血压的关系。方法 2010年1-5月在苏州市金阊区进行了高血压及其危险因素的横断面调查,收集研究对象的人口统计学资料、疾病史、高血压家族史等,测量血压、身高、体质量、腰围等指标;并检测血糖、血脂、血尿酸及尿微量白蛋白、尿肌酐水平。按照性别相同,年龄相差±4岁为条件采用1∶1配对的病例对照方法从该横断面研究中选择高血压患者197例及正常血压者197人,于2016年5月检测这197对研究对象血清中Klotho蛋白的浓度,并进行组间比较。按照Klotho蛋白水平的四分位数(<206.48,206.48~290.48,209.49~430.27,>430.27ng/L)进行分组,采用条件Logistic回归分析血清Klotho蛋白水平与高血压的关系。结果 197对研究对象中男性60对,女性137对,年龄(51.7±8.7)岁,血清Klotho蛋白水平中位数(P_(25)~P_(75))为290.48(206.48~430.27)ng/L,其中高血压患者血清Klotho蛋白水平低于正常血压者[269.67(206.22~359.83)比313.95(218.46~483.39)ng/L,P=0.004]。单因素Logistic分析显示,与Klotho蛋白水平最高四分位组相比,第1、2、3分位组患高血压的OR(95%CI)分别为2.46(1.40~4.31),2.24(1.24~4.02)和1.98(1.12~3.51)。在调整年龄、生活方式、高血压家族史、体质量指数、血糖、血脂、尿酸、尿微量白蛋白水平等因素后,与Klotho蛋白水平最高四分位组比较,其余3组患高血压的OR(95%CI)分别为2.01(1.08~3.71),2.29(1.20~4.39)和1.55(0.82~2.92)。结论低水平的血清Klotho蛋白与高血压患病风险呈正相关。

Objective To examine the relationship between the serum Klotho protein and hypertension in adults. Methods A cross-sectional study was conducted in Jinchang district of Suzhou city from January to May 2010. Subjects＇ data on demographic, lifestyle, medical history, family history of hypertension, height, weight, waist and blood pressure was collected and levels of fasting blood glucose, serum uric acid, lipid levels, and microalbumin were checked. Based on the cross-sectional study, 197 hypertensives and 197 normtensives were selected as research subjects using a 1 ： 1 matched case-control study, and serum Klotho level was tested in May 2016. The subjects were divided into four groups based on the quartile level of Klotho protein （〈206.48, 206.48-290.48, 209.49- 430. 27, 〉430.27 ng/L） and the relationship between serum Klotho protein level and hypertension was analyzed by conditional Logistic regression analysis. Results Of 197 pairs of subjects, 60 pairs were males and 137 pairs were females. The average age of all subjects was （51.7 ±8.7） years old. The median （P25-P75 ） serum Klotho protein level was 290.48 （206.48-430.27） ng/L with the levels in hypertensives lower than in normotensives [269.67 （206.22-359.83） vs 313.95（218.46-483.39） ng/L, P=0. 004]. The univariate conditional Logistic regression showed that compared to subjects in highest quartile Klotho level group, subjects in the first, second and third quartile Klotho level groups had higher risk for hypertension with corresponding ORs （95 % CI） of 2.46 （1.40-4.31）, 2.24 （1.24-4.02） and 1.98 （1.12-3.51） respectively. After adjustment of covariates including age, lifestyle, family history of hypertension, body mass index, fasting blood glucose, serum uric acid, lipid levels, and microalbumin, compared to subjects with the highest quartile Klotho group, ORs （95% CI） of hypertension in other three Klotho quartile groups were 2.01（1.08-3.71）, 2.29（1.20-4.39） and 1.55（0.82-2.92）. Conclusion The low level of serum Klotho protein was positively correlated with risk of hypertension.