4-苯甲酰基-L-苯基丙氨酸的合成方法研究进展

Progress in the Preparation of L-4-Benzoylphenylalanine

4-苯甲酰基-L-苯基丙氨酸是含有二苯甲酮结构的非天然氨基酸。其所含的二苯甲酮结构在特定紫外光线波长照射下能够发生电子跃迁,并和邻近大分子(比如蛋白质)中的氨基酸残基形成共价键,起到了对大分子中特定结构位置的定位作用。依照时间的先后,对目前所报道4-苯甲酰基-L-苯基丙氨酸的合成方法进行了综述。比较了它们各自的优缺点,并提出可能的改进方法,对实际合成工作具有指导意义。

L-4-Benzoylphenylalanine is synthetic amino acid containing the structure of benzophenone. Upon irradiation at the relevant wavelength, benzophenone will generate a triplet ketyl biradical that can react with pro the benzoylphenylalanine was definitely worthwhile and also received extensive attentions. In this article, current methods used to synthesize this compound were reviewed to compare their respective characteristics, which had a guiding significance for the practical work.