胰腺神经内分泌肿瘤诊断及治疗进展

Pancreatic Neuroendocrine Neoplasms:Advances in Diagnosis and Treatment

胰腺神经内分泌肿瘤(pancreatic neuroendocrine neoplasms,PNENs)是少见且异质性大的肿瘤,近几十年来发病率不断上升,肿瘤的分期和分级是影响预后的重要因素。手术是局限期PNENs的主要治疗方法,生长抑素类似物(somatostatin analogues,SSAs)能够缓解激素分泌过多的症状并对控制肿瘤发展有一定作用。对于进展期、转移病灶的治疗,肽类受体放射性核素及联合化疗是可以选择的治疗手段。近期对于信号通路的研究发现靶向治疗也具有一定的抗肿瘤活性,更有效的治疗方法值得我们探索。

Pancreatic neuroendocrine neoplasms are rare and heterogeneous tumors that have been increasing in incidence over the last decades. The survival of PNENs patients depends greatly on stage and grade. Surgery is the mainstay of treatment for localized PNENs. Somatostatin analogs was useful in alleviating the symptoms of excessive hormone secretion and can control the tumor to progress. Other approaches for advanced disease include local therapy,peptide receptor radionuclide therapy and systemic chemotherapy. Recent advances concerning signaling pathways allowed the development of novel targeted therapies. However,there is a supreme need to probe more effective treatment with evidence-based recommendations.