神经激肽1受体拮抗剂预防蒽环类药物所致恶心呕吐的研究进展

The research progress of NK-1 receptor antagonists on prevention of nausea and vomiting induced by anthracyclines

神经激肽-1受体(NK1R)拮抗剂联合5羟色胺3(5-HT3)抑制剂和地塞米松的标准三联止吐方案广泛用于预防蒽环类药物所致的恶心呕吐。近年不同NK1R拮抗剂及其给药方式,与不同5-HT3抑制剂和其他止吐药物联合用于防治蒽环类化疗所致恶心呕吐的研究进展迅速。本文就NK1R拮抗剂在预防蒽环类药物所致恶心呕吐中的作用及机制作一综述。

The neurokinin-1 receptor（ NK1 R） antagonist combined with 5-hydroxytryptamine-3（ 5-HT3） inhibitors and dexamethasone triple standard antiemetic regimens is widely used on the revention of nausea and vomiting induced by anthracycline drugs. In recent years,the research of different NK1 R antagonist and the administration method,and with different 5-HT3 inhibitors and other antiemetic regimens is progressing rapidly. This article summarized the effects and mechanisms of NK1 R antagonists on prevention of nausea and vomiting induced by anthracyclines.