irisin基因多态性对中青年高血压患者靶器官功能损害的影响

Effect of irisin gene polymorphism on target organ dysfunction in young and middle-aged hypertensive patients

目的探讨irisin基因多态性对中青年高血压患者靶器官功能损害的影响。方法自2016年6月—2017年8月,前瞻性收集浙江医院诊治的中青年高血压患者100例作为观察组,同期收集100例健康成人作为对照组。比较2组irisin基因的多态性分布。同时分析中青年高血压患者靶器官功能损害与irisin基因多态性的关系。结果与对照组比较,观察组患者血清irisin表达水平显著降低[(2.52±0.75)μg/ml vs.(2.97±0.80)μg/ml,P<0.001]。观察组rs16835198基因型为TT、GT和GG的例数分别为20、38和42例,对照组分别为29、48和23例,差异有统计学意义(P=0.015)。与irisin≥3μg/ml的患者比较,Irisin<3μg/ml的患者颈动脉内膜中膜厚度显著增高[(1.27±0.17)mm vs.(1.19±0.16)mm,P=0.019];射血分数(%)显著降低[(59.88±4.87)%vs.(63.28±5.29)%,P=0.001]。rs16835198基因型为GG、GT和TT的中青年高血压患者颈动脉内膜中膜厚度分别为(1.32±0.18)mm、(1.16±0.17)mm、(1.21±0.18)mm,差异有统计学意义(P<0.05)。结论 irisin基因在中青年高血压患者中呈多态性分布,与患者靶器官功能损害有关。

Objective To investigate the effect of irisin gene polymorphism on target organ dysfunction in young and mid- die-aged hypertensive patients. Methods From June, 2016 to August, 2017, 100 young and middle-aged hypertensive patients in our hospital were selected as an observation group, and 100 healthy adults were served as a control group. The polymorphic distributions of irisin genes between the two groups were compared. At the same time, the relationship be- tween target organ dysfunction and irisin gene polymorphism in young and middle-aged hypertensive patients were ana- lyzed. Results When compared with the control group, the observation group patients got decreased serum irisin expres- sion [ （2.52 ±0.75） μg/ml vs. （2.97 ±0.80） μg,/ml, P 〈0.001 ]. The cases of rs16835198 genotype TT, GT and GG in the observation group were 20, 38 and 42, respectively, while they were 29, 48 and 23 in the control group with a statistically significant difference （P = 0.015 ）. When compared with the patients with irisin ≥ 3 μg/ml, patients with Irisin 〈3 I^g/ml got increased thickness of carotid artery intima [ （1.27 ± 0. 17） mm vs. （1.19 ± 0.16） mm, P = 0.019） ] and decreased level of ejection fraction [ （59.88 ± 4.87）% vs. （63.28 ± 5.29）%, P = 0.001 ]. The carotid artery intima in young and middle-aged hypertensive patients with GG, GT and Tr of rs16835198 were （1.32 ±0.18） mm, （ 1.16 ± 0.17 ） mm and （ 1.21 ± 0.18 ） mm, and there was a statistically significant difference （ P 〈 0.05 ）. Con- clusion The irisin gene is polymorphic distribution in young and middle-aged hypertensive patients, which is related to the impairment of target organ function in patients.