长期服用阿司匹林对脑出血周围水肿组织的影响

Effect of long-term aspirin taking on brain edema after cerebral hemorrhage

目的探讨长期服用阿司匹林脑出血患者与未服用阿司匹林脑出血患者周围组织水肿的差异。方法采用免疫组化方法检测水通道蛋白(aquaporin-4,AQP4)在29例长期服用阿司匹林脑出血及31例未服用阿司匹林脑出血患者血肿周围水肿组织中的表达,并进行统计学分析。结果AQP4在长期服用阿司匹林脑出血水肿组织中的表达结果:阴性4例,弱阳性11例,中度阳性7例,强阳性7例;在未服用阿司匹林脑出血水肿组织中的表达结果:阴性5例,弱阳性10例,中度阳性8例,强阳性8例,两组比较差异无统计学意义(P>0.05)。结论长期服用阿司匹林并不加重脑出血周围组织水肿程度。

Objective The difference of brain edema after cerebral hemorrhage between the patients who had taken aspirin long-term and other patients who had not taken aspirin was studied. Methods The aquporin-4（AQP4）was detected by immunopositive in the edema brain of cerebral hemorrhage of 29 cases who had taken aspirin for a long-term and 31 cases did not take aspirin. The results were analyzed by statistics software. Results The expression of AQP4 in the brain tissues surrounding edema of 29 cases taking aspirin for a long time were negative in4 cases,weak positive in 11 cases,moderate positive in 7 cases and strong positive in 7 cases. But the expression of31 cases without aspirin in-take was negative in 5 cases,weak positive in 10 cases,moderate positive in 8 cases and strong positive in 8 cases. There was no significant difference in the positive expression between aspisin taking group and no aspirin taking group（P〈0. 05）. Conclusion A long-term aspirin in-take does not affect the brain edema of patients with cerebral hemorrhage.