不同剂量二甲双胍对有生育要求的早期子宫内膜癌患者的疗效及其机制

Efficacy and Mechanism of Different Doses of Metformin on Early Endometrial Cancer Patients with Fertility Requirements

目的分析探究二甲双胍通过调节PI3K/AKT信号通路改善有生育要求的早期子宫内膜癌患者的机制。方法选取我院收治的经病理学检查确诊为早期子宫内膜癌的有生育要求的患者90例,随机分为研究组和对照组,分别应用高、低浓度的二甲双胍药物对患者进行治疗。比较治疗前后两组患者PTEN基因、PIP2及IP3的含量差异、治疗满意度、治疗有效率以及治疗结束后3、6、9个月两组患者的疾病复发率。结果研究组患者的治疗有效率和治疗满意度明显高于对照组(P<0.05);治疗后3个月开始,研究组患者的疾病复发率明显低于对照组(P<0.05);治疗后研究组患者PTEN基因表达量、IP3含量增加幅度及PIP2含量降低幅度明显大于对照组(P<0.05)。结论适当提高二甲双胍的浓度可明显优化早期子宫内膜癌的治疗有效率,降低不良反应发生率,增加患者体内抑癌基因的表达量,促进PIP2向IP3转化,具有较高的临床指导意义。

Objective To explore the mechanism of metformin in the improvement of early endometrial cancer patients with reproductive requirements by regulating the PI3K/AKT signaling pathway. Methods 90 early endometrial cancer patients with fertility requirements in our hospital were selected and they were randomly divided into research group and control group. The patients in the two groups were treated with metformin drugs of high and low concentration respectively. PTEN gene expression level and the content of PIP2 and IP3 were compared between the two groups before and after treatment. Treatment satisfaction, disease treatment efficiency, and the recurrence rate of patients in the two groups were compared after 3, 6, 9 months of treatment respectively. Results In the research group, the effective rate and treatment satisfaction both were significantly higher than those of the control group （P〈0.05）. Three months of treatment later, the recurrence rate of the disease of the research group was significantly lower than that of the control group （P〈0.05）. PTEN gene expression level and the increase of IP3 content of patients in the research group after treatment was significantly greater than those in the control group. Yet the decrease of PIP2 content was greater in the research group than in the control group （P〈0.05）. Conclusion Boosting the concentration of metformin appropri-ately can significantly improve the treatment efficiency of endometrial carcinoma in the early stage, reduce the incidence of adverse reactions in patients, and increase the expression level of tumor suppressor genes and the PIP2 conversion to IP3. It is of high clinical significance.