艾拉光动力联合咪喹莫特对基底细胞癌患者免疫指标的影响

The Effects of Ella Light Power Combined with Imiquimod Cream on Basal Cell Carcinoma

目的研究艾拉光动力联合咪喹莫特对基底细胞癌患者T细胞亚群及NK细胞的影响。方法选取2014年2月至2015年1月期间本院收治的72例基底细胞癌患者,根据随机数字法分为观察组和对照组,每组36例。对照组给予波长为635 mm的艾拉光动力照射,总能量为100 MJ·cm^(-2),输出功率为300 MW,根据光斑面积计算照射时间,每周进行1次治疗,共治疗4次。观察组在上述基础上采用5%咪喹莫特软膏涂抹于病变部位及周围处。比较两组患者治疗前后免疫指标变化,评价两组患者治疗后的临床疗效、美容效果及不良反应的发生情况。结果观察组CD3^+细胞、CD4^+细胞、CD4/CD8比值及NK细胞显著高于对照组(P<0.05),CD8^+细胞显著低于对照组(P<0.05);观察组治疗总有效率和美容效果的优良率均显著高于对照组(P<0.05);两组不良反应的发生情况比较,差异无统计学意义(P>0.05)。结论艾拉光动力联合咪喹莫特治疗基底细胞癌能明显提高患者的临床疗效和美容效果,且安全性高,可能与改善患者的T细胞亚群及NK细胞有关。

Objective To study the influence of Ella light power combined with imiquimod cream in treatment of basal cell carcinoma patients and its effects on immune indexes. Methods During February 2014 to January 2015, 72 basal cell carcinoma patients in our hos-pital were divided into observation group and control group by random, 36 cases in each group. The control group was given 635 nm Ella light power shining once a week and last for 4 weeks, the power was 300 MW, gross energy was 100 MJ · cm-2 and the shining time was ac-cording the illuminance area of patients. The treatment for the observation group was based on the foundation of the control group, plus 5% imiquimod cream covering on the lesion skin. Before and after treatment, the immune indexes changes of the two groups were compared, the clinical efficacy, cosmetic effect and adverse reactions of the two groups were evaluated after treatment. Results The levels of CD3＋, CD4＋ and NK cells and CD4/CD8 were significantly higher in the observation group than in the control group, while that of CD8＋ were significantly lower in the observation group than in the control group （P〈0.05）. In the observation group, total efficacy was significantly higher than in the control group （P〈0.05）. Moreover, the cosmetic effect was significantly better in observation group than in control group （P〈0.05）. Conclu-sion Ella light power combined with imiquimod cream can obviously safely improve the T cell subsets and NK cells, clinical curative effect as well as cosmetic effect of basal cell carcinoma patients.