晚期肺癌患者应用培美曲塞+顺铂化疗联合综合性心理干预的效果分析

The Effect of Pemetrexed plus Cisplatin Chemotherapy Combined with Comprehensive Psychological Intervention on Patients with Advanced Lung Cancer

目的探究晚期肺癌患者在培美曲塞联合顺铂化疗基础上联合综合性心理干预的效果及对生存质量的影响。方法选取我院收治的160例肺癌晚期患者,随机分为对照组(n=80)和研究组(n=80)。对照组患者在培美曲塞联合顺铂化疗治疗基础上加以常规护理干预,研究组患者在培美曲塞联合顺铂化疗的基础上加以综合性心理干预,观察对比两组患者的治疗有效率、生活质量评分、护理满意度以及焦虑抑郁评分。结果研究组患者的护理满意度显著高于对照组患者(P<0.05);干预前两组患者在社会功能、躯体功能、角色功能以及认知功能等方面无明显差异(P>0.05),干预后研究组患者的生活质量评分显著高于对照组患者(P<0.05);研究组患者治疗有效率明显高于对照组患者(P<0.05);干预前两组患者焦虑抑郁评分无明显差异(P<0.05),干预后研究组患者SAS、SDA评分明显低于对照组患者(P<0.05)。结论在培美曲塞联合顺铂化疗的基础上加以综合性心理干预可显著改善患者的生活质量,并且临床疗效好,护理满意度高,值得临床上进一步推广和使用。

Objective To explore the effect of combined psychological intervention based on pemetrexed and cisplatin chemotherapy in patients with advanced lung cancer and its impact on the quality of life. Methods 160 patients with advanced lung cancer were randomly divided into control group （n=80） and study group （n=80） in our hospital, the patients in the control group were given routine nursing inter-vention and pemetrexed combined with cisplatin. the patients in the study group were given comprehensive psychological intervention on the basis of pemetrexed combined with cisplatin. The treatment efficiency, quality of life score, nursing satisfaction, and anxiety depression score of patients between the two groups were observed and compared. Results the nursing satisfaction of patients in the study group was signifi-cantly higher than that in the control group （P〈0.05）; the social function, physical function, role function, and cognitive function between the two groups had no significant difference before intervention （P〉0.05）, life quality score prognosis of patients in study group was significantly higher than that in control group （P〈0.05）; the effective rate of patients in study group was significantly higher than that in the control group （P〈0.05）; the anxiety and depression scores of patients between the two group had no significant difference （P〈0.05） before the interven-tion; the SAS and SDA of patients in study group were significantly lower than those in the control group patients （P〈0.05）. Conclusion comprehensive psychological intervention based on pemetrexed combined with cisplatin chemotherapy can significantly improve the quality of life of patients, has high clinical efficacy, and patients’ satisfaction. It is worthy of further promotion and application in clinical.