首发抑郁障碍患者及抑郁易感者静息态脑功能磁共振的研究

Resting-state functional magnetic resonance imaging study in first-episode depression and subjects at high risk for depression

目的:探讨首发抑郁障碍患者及抑郁易感者静息态下脑功能,探索抑郁症发病及抑郁易感的病理生理学机制。方法:采用静息态功能磁共振成像技术(rs-fMRI)对23例首发未服药抑郁障碍患者、26例抑郁易感者和15例健康志愿者行rs-fMRI扫描,应用局部一致性分析方法(ReHo)比较各组间的差异脑区。结果:相对正常组,患者组右额上回、双侧前扣带回ReHo值升高,右壳核、小脑后叶及颞上回ReHo值降低;易感组左壳核及右前扣带回ReHo值升高,左舌回、额上回及右颞上回ReHo值降低。相对患者组,易感组右壳核、小脑后叶、颞上回及扣带回ReHo值升高,左楔前叶及额上回ReHo值降低(P均<0.05)。结论:抑郁障碍是一个涉及多脑区、多系统的疾病;这些异常脑区可能是抑郁易感的病理脑区。

Objective： Using resting-state functional magnetic resonance imaging（ rs-fMRI）,we observed the features of brain function in first-episode patients with depression and subjects at high risk for depression during resting state,explored the pathological mechanism of the susceptibility to depression. Method： 23 first-episode、medication-naive adult patients with depression,26 subjects group at high risk for depression and 15 healthy control group were scanned using 3. 0 T MRI during resting state. ReHo analysis were used to detect the between-group differences. Results： Comparing with the healthy group,the depression group showed increased ReHo value in the right superior frontal gyrus、bilateral anterior cingulate gyrus,and decreased in the right putamen、right cerebellum posterior lobe and right superior temporal gyrus; The subjects at high risk for depression showed increased ReHo value in the left putamen and right anterior cingulate gyrus,and decreased in the left lingual gyrus、left superior frontal gyrus and right superior temporal gyrus. Comparing with the depression group,the subjects at high risk for depression showed increased ReHo value in the right putamen、right cerebellum posterior lobe、right superior temporal gyrus and right cingulate gyrus,and decreased in the left precuneus and left superior frontal gyrus. Conclusion： Patients with depression and subjects at high risk for depression had abnormal brain regions in the rest state,and evidenced that depression is a disease involving more brain areas and systems. So,we can speculate that these abnormal brain regions may be the potential nerve pathological mechanism of depression and susceptible to depression.