组蛋白H3甲基化修饰与心脏发育的研究进展

Progress in histone H3 methylation and heart development

哺乳动物心脏发育需要干细胞的精确定位、增殖以及心肌祖细胞的分化等过程（[1]）,这一系列过程涉及到多个心脏目的基因的精确编程调控。心脏基因组装于致密的染色质结构中,而染色质的基本单位核小体主要是由147 bp碱基对组成的线性DNA盘绕于组蛋白八聚体外侧构成（[2]）。心脏目的基因的表达除了与基因序列相关外,还与心脏关键转录因子及基因组染色质结构修饰因子等表观遗传学途径密切相关。

Congenital heart disease is one of the main types of birth defect. The mammalian heart developmental progress requires precise gene patterning in time and space. In addition to the gene sequence,recent research showed that the regulation of core cardiac gene expression has been proved to be closely related to cardiac transcription factors as well as the modification of genomic architecture of the histone. Methylation of histone might be the key nodes in the regulation of cardiac gene expression and chromatin structure. This review focuses on the role of histone H3 methylation in heart development process,which may lay a foundation for the prediction of epigenetic modification of congenital heart disease.