达芬奇机器人与胸腹腔镜联合辅助McKeown食管癌根治术后患者短期疼痛的非随机对照研究

Short-term postoperative pain of robot-assisted versus thoracolaparoscopic McKeown esophagectomy for esophageal carcinoma: A non-randomized controlled trial

目的评估行达芬奇机器人辅助McKeown食管癌根治手术与传统胸腹腔镜联合手术的食管癌患者术后短期疼痛的差异。方法纳入2016年9月至2017年2月在四川大学华西医院胸外科食管癌患者77例。按手术方式将患者分为达芬奇机器人组(行机器人辅助McKeown食管癌根治术)和传统腔镜组(行传统胸腹腔镜联合手术)。传统腔镜组38例,其中男30例、女8例,平均年龄(60.80±6.20)岁。达芬奇机器人组39例,其中男35例、女4例,平均年龄(60.90±7.20)岁。结果术后镇痛药物的使用剂量在两组中无差异。传统腔镜组和机器人组术后第1、3、5、6和7 d平均疼痛视觉模拟评分分别为3.20±1.10和2.70±0.90(P=0.002),2.75±0.96和2.40±0.98(P=0.030),2.68±1.08和2.02±0.80(P=0.005),2.49±0.99和1.81±0.88(P=0.003),2.27±0.83和1.51±0.61(P<0.001),差异有统计学意义。其他观察指标的差异均无统计学意义。结论达芬奇机器人辅助McKeown食管癌切除手术较传统胸腹腔镜手术的患者术后短期疼痛较轻,但是对长期疼痛的影响有待进一步研究。

Objective To investigate the short-term postoperative pain between robot-assisted and thoracolaparoscopic McKeown esophagectomy for esophageal carcinoma. Methods We prospectively analyzed clinical data of 77 patients with esophageal carcinoma in our hospital between September 2016 and February 2017. The patients were allocated into two groups including a robot group and a thoracolaparoscopic group. The patients underwent robot assisted McKeown esophagectomy in the robot group and thoracolaparoscopic McKeown esophagectomy in the thoracolaparoscopic group. There were 38 patients with 30 males and 8 females at average age of 60.80±6.20 years in the thoracolaparoscopic group, and 39 patients with 35 males and 4 females at average age of 60.90±7.20 years in the robot group. Results There was no statistical difference between the two groups in terms of the postoperative usage of analgesic drugs. The patients in the robot group experienced less postoperative pain on postoperative day 1, 3, 5, 6 and 7 than the patients in the thoracolaparoscopic group. The mean value of visual analogue scale （VAS） on postoperative day 1, 3, 5, 6 and 7 for the robot group and the thoracolaparoscopic group was 3.20±1.10 versus 2.70±0.90 （P=0.002）, 2.75±0.96 versus 2.40±0.98 （P=0.030）, 2.685±1.08 versus 2.02±0.8 （P=0.005）; 2.49±0.99 versus 1.81±0.88 （P=0.003）, 2.275±0.83 versus 1.51±0.61 （P〈0.001）, respectively. Conclusion Compared with the thoracolaparoscopic group, patients receiving robot assisted McKeown esophagectomy experience less postoperative short-term pain. However, the long-term postoperative pain for these patients needs to be further studied.