有氧游泳运动对小鼠心肌Na^+-K^+-ATP酶活性的影响

Effects of Aerobic Swimming Exercise on the Activity of Myocardial Na^+-K^+-ATP Enzyme in Mice

目的观察有氧游泳运动对小鼠心肌Na^+-K^+-ATP酶的影响。方法雄性ICR小鼠30只,随机分为正常对照组、有氧运动组、力竭运动组。观察有氧运动对小鼠体重、脏器系数、血清超氧化物歧化酶(SOD)、丙二醛(MDA)及心肌肌浆网Na^+-K^+-ATP酶活性的影响。结果与正常对照组比较,有氧运动可显著提高小鼠血清SOD水平(P<0.05),降低MDA水平(P<0.05),增加小鼠心肌Na^+-K^+-ATP酶的活性(P<0.05)。结论有氧运动可以增强小鼠心肌Na^+-K^+-ATP酶的活性,可能与其降低机体自由基水平有关。

Objective To observe the effects of aerobic swimming exercise on the myocardial Na＋-K＋-ATP enzyme in mice. Methods 30 male ICR mice were randomly divided into normal control group, aerobic exercise group and exhaustive exercise group, to observe the effects of aerobic exercise on the body weight, organ coefficient, serum superoxide dismutase （SOD）, malondialdehyde （MDA） and cardiac sarcoplasmic reticulum Na＋-K-ATP enzyme activity in mice. Results Compared with the normal control group, aerobic exercise could significantly improve the level of serum SOD in mice （P〈0.05）, decrease the MDA level （P〈0.05）, and increase the myocardial Na＋-K-ATP enzyme activity of mice （P 〈0.05）. Conclusions Aerobic exercise can enhance the activity of myocardial Na＋-K-ATP enzyme activity in mice that may related with the decrease of the free radical level.