多烯磷脂酰胆碱联合思美泰治疗胆汁瘀积性黄疸的疗效观察

Observation on the Curative Effect of Polyene Phosphatidylcholine Combined with Transmetil in the Treatment of Cholestatic Jaundice

目的探讨多烯磷脂酰胆碱联合思美泰治疗胆汁瘀积性黄疸的疗效。方法选择我院2015年2月至2017年12月收治的胆汁瘀积性黄疸患者50例为研究对象,随机分为两组各25例。对照组患者予以思美泰静脉滴注治疗,观察组患者予以思美泰静脉滴注联合多烯磷脂酰胆碱注射液静脉滴注治疗。比较两组的临床疗效、生化检查指标以及生活质量评分。结果观察组的治疗总有效率为96.0%,显著高于对照组的76.0%(P<0.05)。治疗后,观察组的血清总胆红素(TBi L)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平均显著低于对照组,健康感觉、心理功能、躯体健康、生活态度及社会功能等生活质量指标评分均显著高于对照组,差异有统计学意义(P<0.05)。结论多烯磷脂酰胆碱联合思美泰治疗可有效提高胆汁瘀积性黄疸患者的临床疗效,改善各项生化指标,提高生活质量。

Objective To explore the curative effect of polyene phosphatidylcholine combined with transmetil in the treatment of cholestatic jaundice. Methods 50 cases of patients with cholestatic jaundice admitted to our hospital from February 2015 to December 2017 were selected as research objects. All cases were randomly divided into two groups, with 25 cases in each group. The control group was treated with transmetil for intravenous drip, while the observation group was treated with transmetil for intravenous drip ＋ polyene phosphatidylcholine injection for intravenous drip. The clinical curative effect, indicators of biochemical examination and scores of life quality were compared between two groups. Results The total effective rate of treatment of observation group was 96.0%, significantly higher than 76.0% of control group （P〈0.05）. After treatment, the levels of serum total bilirubin （TBiL）, alanine aminotransferase （ALT） and aspartate aminotransferase （AST） of observation group were significantly lower than those of control group, and the scores of indicators of life quality including health sensation, psychological fimction, physical health, life attitude and social function were significantly higher than those of control group （P 〈0.05）. Conclusions Polyene phosphatidylcholine combined with transmetil in the treatment of patients with cholestatic jaundice can effectively improve the clinical curative effect, improve the biochemical indicators, and improve the quality of life.