纳洛酮联合醒脑静对肝性脑病患者的治疗效果

The treatment effect of naloxone combined with Xingnaojing Injection on patients with hepatic encephalopathy

目的:探讨纳洛酮和醒脑静注射液联合治疗肝性脑病的临床效果。方法:选择收治的肝性脑病患者58例,随机分为观察组和对照组,每组29例。两组均给予肝性脑病常规治疗,对照组同时给予纳洛酮治疗,观察组同时给予纳洛酮联合醒脑静注射液治疗。观察两组肝功能和血氨水平改变情况。结果:观察组治疗前肝功能(AST、ALT)和血氨水平和对照组治疗前肝功能和血氨水平比较,差异无统计学意义(P>0.05)。观察组治疗后肝功能和血氨水平分别和对照组治疗后比较,差异有统计学意义(P<0.05)。观察组总有效率(显效和有效所占比例)高于对照组,差异有统计学意义(P<0.05)。结论:纳洛酮联合醒脑静注射液能够显著降低肝性脑病患者血氨水平,改善功能,效果显著。

Objective To explore the clinical effect of naloxone and Xingnaojing Injection in treatment of hepatic encephalopathy. Method 58 patients with hepatic encephalopathy treated in our hospital were randomly divided into the observation group and the control group,with 29 cases in each group. The two groups were given conventional treatment of hepatic encephalopathy,while the control group received naloxone treatment,the observation group was given naloxone combined with Xingnaojing injection treatment. The changes of liver function and blood ammonia level were observed in the two groups. Results There was no significant difference in liver function（AST,ALT） and blood ammonia level between the observation group and the control group before treatment（P〈0. 05）. After treatment,the liver function and the level of blood ammonia in the observation group were compared with the control group,and the difference was statistically significant（P〈0. 05）. The total effective rate（significant and effective proportion） of the observation group was higher than that of the control group,and the difference was statistically significant（P〈0. 05）. Conclusion Naloxone combined with Xingnaojing injection can significantly reduce the level of blood ammonia in patients with hepatic encephalopathy,and improve function,The effect is remarkable.