无创通气联合气道雾化吸入特布他林和布地奈德治疗慢性阻塞性肺疾病的疗效观察

Efficacy of noninvasive ventilation combined with inhalation of terbutaline and budesonide in the treatment of COPD

目的:探讨无创通气联合气道雾化吸入特布他林和布地奈德治疗慢性阻塞性肺疾病(chronic obstructive pulmonary diseases,COPD)的临床效果及安全性分析。方法:选取128例COPD患者为研究对象,随机分为试验组与对照组,各64例。患者年龄、性别、病程长短差异无统计学意义(P>0.05)。所有患者均采取无创正压通气的基础治疗,试验组加做气道雾化吸入特布他林和布地奈德治疗,以最终临床总有效率为评价两组试验结果的指标,同时记录患者治疗前后24 h、48 h、72 h动脉血气指标(PaCO_2、PaO_2、pH值)、呼吸频率(RR)和心率(HR)情况,P<0.05为差异具有统计学意义。结果:经治疗,两组患者临床症状均有不同程度缓解,试验组总有效率为93.75%(60例),对照组总有效率为76.56%(49例),试验组总有效率明显高于对照组。治疗后两组患者动脉血气指标、心率及呼吸频率均有改善,试验组症状缓解程度明显高于对照组,差异均具有统计学意义(P<0.05)。结论:无创通气联合气道雾化吸入特布他林和布地奈德治疗COPD治疗效果显著,总有效率高,能有效改善COPD患者血气指标、心率、呼吸频率各项指标,具有临床推广意义。

Objective To investigate the noninvasive ventilation combined with airway inhalation of terbutaline and budesonide in the treatment of chronic obstructive pulmonary disease（chronic obstructive pulmonary diseases,COPD） analysis of the clinical effect and safety. Method 128 cases of COPD patients were selected as the experimental object,they were randomly divided into experiment group and control group,64 cases in each group,regardless of age,gender,duration of disease affecting the differences,no statistically significant difference of all patients（P〈0. 05）. Both take no basis for the treatment of noninvasive positive pressure ventilation in the experimental group with airway inhalation of terbutaline and budesonide in the treatment,the total efficiency to the final clinical evaluation of two groups of test. Of the index,at the same time were recorded before and after treatment 24 h,48 h,72 h,arterial blood gas（PaCO2,PaO2,pH）,respiratory the frequency（RR） and heart rate（HR）,with SPSS as the statistical tool for data analysis,The difference was statistically significant（P〈0. 05）. Results The results of two groups of patients after treatment of clinical symptoms were alleviated,experimental group total effective rate was 93. 75%（60 cases） and control group The total effective rate was 76. 56%（49 cases）,the total efficiency of experimental group was significantly higher than the control group. After treatment two groups of patients with arterial blood gas index,heart rate and respiratory rate were improved,symptoms relieved degree of test group was significantly higher than the control group,the difference was statistically significant（P〈0. 05）. Conclusion Noninvasive ventilation combined with airway inhalation Tebu terbutaline and budesonide in the treatment of COPD treatment,the total effective rate is high,can effectively improve the blood gas indexes,COPD indexes of patients with heart rate,respiratory rate,has clinical significance.