中医药调控心血管疾病自噬研究进展

Research progress of traditional Chinese medicine in regulating the autophagy of cardiovascular diseases

自噬是真核细胞维持稳态的一种高度保守的降解过程,在心肌缺血/再灌注损伤、动脉粥样硬化等多种心血管疾病的发生、发展中起到调控作用,是治疗心血管疾病的新靶点。阴阳自和、气虚痰瘀、肝主输泄等中医理论与自噬密切相关,中医药对心血管疾病的保护作用可以通过自噬途径实现。本文重点讨论心血管疾病中的自噬,并对近年来中医药调节心血管疾病自噬的研究进展作一简要概述。

Autophagy is a highly conservative process in which eukaryotic cells maintain homeostasis and it plays an regulatory role in the occurrence and development of cardiovascular disease（CVD） such as myocardial ischemia and reperfusion injury and atherosclerosis, which is a new target for CVD. The theory of traditional Chinese medicine, such as reestablishment to yin-yang equilibrium, phlegm stasis due to deficiency of qi, liver controlling conveyance and dispersion are closely related to autophagy. Many literatures show that the protective effect of TCM on cardiovascular disease is achieved through autophagy. In this paper, the autophagy in CVD is discussed, and a brief overview of the research progress in the regulation of CVD autophagy in Chinese medicine is presented.