冠心舒通胶囊对老年急性心肌梗死经皮冠状动脉介入治疗患者的效果及对其氧化应激、血小板活化功能的影响

The effect of Guanxin Shutong Capsules in the treatment of patients with acute myocardial infarction with percutaneous coronary intervention and its effects on oxidative stress and platelet activation

目的探讨冠心舒通胶囊对老年急性心肌梗死(AMI)经皮冠状动脉介入治疗患者的效果及其氧化应激、血小板活化功能的影响。方法选取2016年2月~2017年9月承德医学院附属医院80例老年AMI经皮冠状动脉介入治疗患者,按随机数字表法分为对照组(常规治疗)和观察组(冠心舒通胶囊),各40例。比较两组治疗的临床效果以及术前、术后超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)水平,血小板活化功能指标[溶酶体膜糖蛋白(CD63)、血小板α颗粒表面膜糖蛋白(CD62p)、单核细胞血小板聚集体(MPA)]含量变化情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者术后SOD、NO水平均高于对照组,MDA水平低于对照组,差异有统计学意义(P<0.05);两组术后CD63、CD62p、MAP含量均低于术前,观察组低于对照组,差异有统计学意义(P<0.05)。结论冠心舒通胶囊能够明显提高老年AMI经皮冠状动脉介入治疗的临床效果,抑制氧化应激及血小板活化,发挥心肌保护作用。

Objective To study the effect of Guanxin Shutong Capsules in the treatment of patients with acute myocar dial infarction（AMI） with percutaneous coronary intervention and its effects on oxidative stress and platelet activation.Methods The 80 elderly patients with AMI undergoing percutaneous coronary intervention in Affiliated Hospital of Chengde Medical Univercity from February 2016 to September 2017 were devided into control group（routine treatment） and observation group（Guanxin Shutong Capsules） according to the random number table method, with 40 patients in each group. The clinical efficacy, the levels of superoxide dismutase（SOD）, malondialdehyde（MDA） and nitric oxide（NO）, and the contents of platelet activation index such as lysosomal membrane glycoprotein（CD63）, platelet alpha granule membrane glycoprotein（CD62p） and monocyte platelet aggregates（MPA） preoperative and postoperative in two groups were compared. Results The total effective rate in the observation group was higher than that of the control group, the difference was statistically significant（P〈0.05）. After operation, the levels of SOD and NO in the observation group were higher than that of the control group, the level of MDA was lower than the control group, the differences were statistically significant（P〈0.05）. After operation, the contents of CD63, CD62p, MAP were lower than before operation in two groups, and the observation group was lower than the control group, the differences were statistically significant（P〈0.05）. Conclusion Guanxin Shutong Capsules can significantly improve the clinical efficacy for elderly patients with AMI undergoing percutaneous coronary intervention, inhibit the oxidative stress and platelet activation, and play the myocardial protection role.