不同脱敏剂对牙齿漂白治疗脱敏效果的临床随机对照试验

Clinical randomized controlled trials of different desensitizers in the treatment of tooth bleaching for desensitization

目的评估不同脱敏剂对接受诊室和家庭牙齿漂白后的患者牙齿敏感发生率和敏感程度的印象。方法 90位受试者随机接受诊室和家庭美白。D组患者45人接受诊室漂白,E组受试者45人接受为期14d的家庭牙齿漂白治疗。D1、E1组为对照组不使用脱敏剂,D2、E2组应用的脱敏剂为5%硝酸钾溶液(Sensoden KF)。D3、E3组为CPP-ACP(tooth mousse)。分别在受试者接受治疗的当天以及之后每隔72h进行牙齿敏感性的评估,总共进行5次。对实验结果进行方差检验和方差分析。结果对于诊室漂白实验组的牙齿敏感发生率要显著低于对照组,对于家庭漂白实验组和对照组之间没有显著区别。结论实验中的脱敏剂可以有效提高诊室美白受试者的牙齿舒适性,家庭美白受试者在治疗过程中不良反应轻微没有充分必要使用脱敏剂。

Objective To evaluate the efficacy of desensitizing agents during tooth bleaching.Methods 90 participants were randomly divided into 6 groups of 15 each.they recived 35% hytrogen peroxide （D groups） or 16 carbamide peroxide （E groups）.D1 and E1 were control group,D2 and E2-potassium nitrate 5%（SensodenKF）,E3、E3-Casein- phosphopeptide-Amorphous calcium phosphate（CPP-ACP） （tooth mousse）.Participants in the control group did not use any desensitizing agent. We assessed TS with Visual Analogue Scale.Assessment point 1 was immediately after the frst participant’ s exposure to the treatments; and points 2, 3, 4, and 5 were every 72 h along.the period of the study.Two-way. ANOVA（considering time and desensitizing as factors） and post-hoc Tukey test （a=0.05） analyzed the data.Results In the control group treated with 35% hydrogen peroxide,TS increased signifcantly on assessment points 1 and 2. The participants who used a 5% potassium nitrate dentifrice and in-offce experimental pastes did not experience TS because of the 35% in-offce bleaching treatment.Conclusion TS caused by 35% hydrogen peroxide in-offce tooth bleaching was controlled by desensitizing agents , TS caused by 16 carbamide peroxide is more tolerable for participants,it’s may not necessary for the apply of desensitizing agents.