阿加曲班治疗急性缺血性脑卒中的疗效

Curative effect of argatroban in the treatment of acute ischemic stroke

目的研究阿加曲班治疗急性缺血性脑卒中的疗效。方法选取西安高新医院2012—2015年住院的急性缺血性脑卒中患者300例,将有完整影像学资料的入组患者随机分为治疗组与对照组。治疗组(n=134)给予阿加曲班,对照组(n=141)给予注射用低分子量肝素钠。治疗1个月后比较两组NIHSS、FMA评分及BI,并观察两组影像学表现。结果治疗后,两组患者的NIHSS、FMA评分及BI均明显改善,且治疗组优于对照组(P<0.05)。治疗组颅内血管再通率、侧枝循环再建率优于对照组;颈动脉斑块好转率优于对照组(P<0.05)。结论阿加曲班治疗急性缺血性脑卒中疗效较佳,且能改善动脉粥样硬化血管。

Objective To study the efficacy of argatroban on acute ischem ic stroke. Methods Three hundred patients with acute ischemic stroke who were hospitalized in Xi＇an Gaoxin Hospital from 2012 to 2015 were enrolled in this study.The patients who had complete imaging data were randomly divided into tereatment goup and control group. The treatment group（n =134） was treated with argatroban; the control group（n =141） was treated with low-molecular-weight heparin sodium. After 1 month of treatment, the NIHSS FMA scores and BI were compared between the two groups; the imaging findings of the two groups were observed. Results After treatment, the NIHSS, FMA scores and BI in both groups significantly improved, and those in the treatment group were superior to the control group（P〈0.05）. The intracranial vascular recanalization rate and collateral circulation reconstruction rate in the treatment group were better than those in the control group; and the improvement rate of carotid plaque was better than that in the control group（P〈0.05）.Conclusion Agatripine is effective in treating acute ischemic stroke, and it can improve atherosclerotic blood vessels.