盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎的临床疗效

Clinical effect of minocycline hydrochloride ointment combined with tinidazole in the treatment of chronic periodontitis

目的探讨盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎的临床疗效。方法选取2016年3月至2017年5月我院收治的慢性牙周炎患者160例,随机分为观察组和参照组,每组80例。参照组给予盐酸米诺环素软膏治疗,观察组给予盐酸米诺环素软膏联合替硝唑治疗,对比观察两组的临床治疗效果及牙周各项指标。结果观察组治疗总效率为96.25%,明显高于参照组的77.50%,差异具有统计学意义(P<0.05);治疗后,观察组的牙龈出血指数(GI)、牙周袋深度(PD)、菌斑指数(PLI)、牙周附着水平(PAL)等各项指标均下降,且观察组优于对照组(P<0.05)。结论盐酸米诺环素软膏联合替硝唑对于牙周炎具有良好的治疗效果,具有临床应用与推广价值。

Objective To investigate the clinical effect of minocycline hydrochloride ointment combined with tinidazole in the treatment of chronic periodontitis. Methods A total of 160 cases of chronic periodontitis patients admitted in our hospital from March 2016 to May 2017 were selected and randomly divided into observation group and control group, with80 cases in each group. The control group was given minocycline hydrochloride ointment, and the observation group was given minocycline hydrochloride ointment combined with tinidazole. The clinical curative effect and periodontal indexes of the two group were compared. Results The total effective rate of the observation group was 96.25%, which was significantly higher than 77.50% of the control group, the difference was statistically significant（P〈0.05）. After treatment, the gingival bleeding index（GI）, periodontal pocket depth（PD）, plaque index（PLI）, periodontal attachment level（PAL） of the two groups decreased, and those of the observation group were significantly better than the control group（P〈0.05）. Conclusion Minocycline hydrochloride ointment combined with tinidazole has good therapeutic effect on periodontitis, and it has clinical application and promotion value.