布地奈德气雾剂联合氨溴索注射液雾化治疗新生儿肺炎的疗效

Efficacy of budesonide aerosol combined with ambroxol injection atomized in the treatment of neonatal pneumonia

目的探讨布地奈德气雾剂联合氨溴索注射液雾化治疗新生儿肺炎的临床疗效。方法将新生儿肺炎患儿100例按随机数字表法分成观察组和对照组,每组50例。观察组患儿给予布地奈德气雾剂联合氨溴索注射液雾化治疗,对照组患儿给予氨溴索注射液雾化治疗,比较两组的治疗效果。结果观察组的临床治疗总有效率明显高于对照组(P<0.05);观察组的临床症状改善时间均明显短于对照组,比较两组的治疗效果(P<0.05);两组患儿治疗前的PCO2和OI值均相当,差异不存在统计学意义(P>0.05),观察组患儿治疗后的PCO2水平显著低于对照组患儿,OI值显著高于对照组患儿(P<0.05)。结论布地奈德气雾剂联合氨溴索注射液雾化治疗新生儿肺炎,可快速改善患儿的各项临床症状和呼吸指数,从而显著提高患儿的临床治疗效果。

Objective To investigate the clinical efficacy of budesonide aerosol combined with ambroxol injection atomized in the treatment of neonatal pneumonia. Methods A total of 100 cases of neonatal pneumonia were randomly divided into observation group and control group, with 50 cases in each group. The observation group was given budesonide aerosol combined with ambroxol injection atomization treatment, and the control group was given ambroxol injection atomization treatment. The effects of the two groups were compared. Results The total effective rate in the observation group was significantly higher than that of the control group（P〈0.05）. The improvement time of clinical symptoms in the observation group were significantly shorter than those in the control group（P〈0.05）. There was no significant difference in PCO2 and OI of the two groups before treatment（P〉0.05）. After treatment, the PCO2 level in the observation group was significantly lower than that in the control group, and the OI score of the observation group was significantly higher than that of the control group, the differences were statistically significant（P〈0.05）. Conclusion Budesonide aerosol combined with ambroxol injection atomization treatment of neonatal pneumonia can quickly improve the clinical symptoms and respiratory index of children, thus it can significantly improve the clinical curative effect of children.