血液灌流联合盐酸戊乙奎醚注射液治疗急性重度有机磷农药中毒对胆碱酯酶复活的影响

Effect of hemoperfusion combined with penehyclidine hydrochloride injection on the recovery of cholinesterase in patients with acute severe organophosphorus pesticide poisoning

目的探讨血液灌流联合盐酸戊乙奎醚注射液治疗急性重度有机磷农药中毒对胆碱酯酶复活的影响。方法 67例急性重度有机磷农药中毒患者,采用简单随机法分为对照组(34例)和观察组(33例),对照组实施常规治疗,观察组行血液灌流联合盐酸戊乙奎醚注射液治疗。观察比较两组患者的治疗效果及清醒时间、胆碱脂酶活性恢复时间、住院时间。结果观察组患者治疗总有效率93.94%明显高于对照组的70.59%,差异具有统计学意义(P<0.05);观察组患者清醒时间、胆碱酯酶复活时间、住院时间分别为(6.21±2.15)h、(8.22±3.45)d、(2.78±0.35)d,明显优于对照组(9.34±2.03)h、(16.27±3.12)d、(3.44±0.69)d,差异具有统计学意义(P<0.05)。结论针对急性重度有机磷农药中毒患者,行血液灌流联合盐酸戊乙奎醚注射液治疗能够促进胆碱酯酶复活,改善患者预后质量,值得推广。

Objective To discuss the effect of hemoperfusion combined with penehyclidine hydrochloride injection on the recovery of cholinesterase in patients with acute severe organophosphorus pesticide poisoning. Methods A total of 67 patients with acute severe organophosphorus pesticide poisoningwere divided by simple random method into control group （34 cases） and observation group （33 cases）. The control group received conventional therapy, and the observation group received hemoperfusion combined with penehyclidine hydrochloride injection for treatment. Observation and comparison were made on wake-up time, cholinesterase reactivation time and hospitalization time between the two groups. Results The observation group had obviously higher total treatment effective rate as 93.94% than 70.59% in the control group, and the difference was statistically significant （P〈0.05）. The observation group had obviously better wake-up time, cholinesterase reactivation time and hospitalization time respectively as （6.21±2.15） h, （8.22±3.45） d and （2.78±0.35） d than （9.34±2.03） h, （16.27±3.12） d and （3.44±0.69） d in the control group, and their difference was statistically significant （P〈0.05）. Conclusion For patients with acute severe organophosphorus pesticide poisoning, combination of hemoperfusion and penehyclidine hydrochloride injection can promote the recovery of cholinesterase, and improve the prognostic quality of patients. It is worthy of promotion.