布拉氏酵母菌预防抗生素相关性腹泻疗效观察

Observing the Curative Effect of Brasilia on Preventing Antibiotic-associated Diarrhea

目的:探讨真菌类微生态制剂-布拉氏酵母菌预防抗生素相关性腹泻的疗效。方法:将2017年11月至2018年2月期间,在妇幼保健院小儿内科一病区病房,急性支气管肺炎住院患儿92例,随机分为两组,干预组46例,对照组46例。两组均给予头孢他啶抗感染及对症支持治疗,其中干预组在上述治疗基础上同时加服布拉氏酵母菌散剂。分别记录干预组与对照组的病人,继发性腹泻的每日大便次数、腹泻发生率、腹泻持续时间,进行统计分析。结果:干预组继发腹泻3例,发病率为6.52%,对照组腹泻12例,发病率为26.08%。干预组在继发腹泻发生率、腹泻持续时间明显优于对照组。结论:布拉氏酵母菌预防抗生素相关性腹泻具有积极的预防作用。

Objective ： To investigate the efficacy of fungal probiotics-Brassicanae in the prevention of antibiotic-associated diarrhea. METHODS ： From November 2017 to February 2018, 92 cases of hospitalized acute bronchopneumonia in a pediatric pediatric department ward were randomly divided into two groups, 46 cases in the intervention group and 46 cases in the control group. Both groups were given ceftazidime for anti-infection and symptomatic and supportive treatment. The intervention group was additionally given a powder of Brassella cerevisiae on the basis of the above treatment. The frequency of daily stool, diarrhea, and duration of diarrhea in patients with interventional and control groups were recorded. Statistical analysis was performed. Results ： In the intervention group,there were 3 cases of secondary diarrhea, the incidence rate was 6. 52 %, and the control group had 12 cases of diarrhea. The incidence rate was 26. 08 %. The incidence of secondary diarrhea and duration of diarrhea were significantly better in the intervention group than in the control group. Conclusion ： Bradschia has a prophylactic effect in the prevention of antibiotic-associated diarrhea.