血清中胃泌素-17、胃蛋白酶原Ⅰ和胃蛋白酶原Ⅱ与Hp感染的相关性分析

Analysis of the correlation between serum gastrin-17,pepsinogen Ⅰ and pepsinogen Ⅱ and Hp infection

目的:探讨血清中胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PG-Ⅰ)和胃蛋白酶原Ⅱ(PG-Ⅱ)与幽门螺旋杆菌(Hp)感染的相关性。方法:按照Hp感染情况将2016年1月—2017年12月诊治且行Hp感染检测的248例患者分为Hp阳性组和Hp阴性组。对比分析两组血清中G-17、PG-Ⅰ和PG-Ⅱ的表达水平。结果:Hp阳性组的PG-Ⅰ和G-17水平显著高于阴性组(P<0.05),而PG-Ⅱ、PGⅠ与PGⅡ比值(PGR)均显著低于阴性组(P<0.05);PG-Ⅰ、PG-Ⅱ和G-17水平为Hp是否感染的影响因素,其中PG-Ⅰ和G-17为Hp感染的危险因素(OR<1,P<0.05),PG-Ⅱ是Hp感染的保护因素(OR>1,P<0.05)。结论:血清中G-17、PG-Ⅰ和PG-Ⅱ与Hp感染显著相关,G-17和PG-Ⅰ是危险因素,PG-Ⅱ对Hp感染的影响尚需进一步研究确定。

Objective： To investigate the correlation between serum gastrin-（-1）7,pepsinogen Ⅰ and pepsinogen Ⅱ and Hp infection. Methods： According to the situation of Hp infection,248 cases of Hp infection were divided into Hp positive infection group and negative infection group from January 2000 to December 2017. The levels of gastrin-（-1）7,pepsinogen Ⅰ and pepsinogen Ⅱ in serum were compared and analyzed. Results： The levels of PG-Ⅰ and G-17 in Hp-positive group were significantly higher than those in negative infection group（ P〈0. 05）,while the levels of PG-Ⅱ,PGⅠand PGⅡ were significantly lower than those of negative infection group（ P〈0. 05）. PG-Ⅰ,PG-Ⅱ and G-17 were the influencing factors of Hp infection. PG-Ⅰ and G-17 were the risk factors of Hp infection（ OR 1,P〈0. 05）,PG-Ⅱ was Hp infection（ P〈0. 05）.Conclusion： G-17,PG-Ⅰ and PG-Ⅱ are significantly associated with Hp infection in serum. G-17 and PG-Ⅰ are the risk factors. PG-Ⅱ is associated with Hp infection the need for further study to determine.