紫杉类与蒽环类方案治疗乳腺癌的疗效与不良反应对比研究

Analysis of curative effect of TC regimen and FAC regimen in patients with breast cancer

目的:观察TC(多西他赛+环磷酰胺)联合方案与FAC(氟尿嘧啶+吡柔比星+环磷酰咹)联合方案治疗乳腺癌患者的疗效及不良反应。方法:将2015年5月—2016年10月进行治疗的乳腺癌患者60例随机均分为对照组和观察组,每组30例。观察组采取TC方案治疗,对照组采取FAC方案新辅助化疗治疗,比较两组患者的临床效果及不良反应。结果:观察组患者的治疗有效率与对照组比较,差异无统计学意义,两者均无严重的不良反应发生,但是骨痛是TC组独特的不良反应,而消化道反应在FAC组较为明显,与观察组比较,差异有统计学意义。结论:两种化疗方案有效率无明显区别,但是FAC化疗方案治疗患者恶心、呕吐等消化道不良反应相对较大,而TC组化疗方案骨痛是其独有的不良反应,但发生率较低,对症处理能够缓解。

Objective： To observe the efficacy and side effects of TC regimen and FAC regimen in the treatment of breast cancer. Methods： Sixty patients with breast cancer who were treated in our hospital from May 2015 to October 2016 were randomly divided into two groups： 30 patients in each group,the control group and the observation group,respectively. The control group was treated with TC regimen. The observation group received FAC regimen neoadjuvant chemotherapy and compared the clinical effect of the two groups. Results： There was no significant difference in the total effective rate of the clinical treatment between the two groups,but the bone pain was the unique adverse reaction of the TC group,while the gastrointestinal reaction was found in the FAC group more obvious,and compared with the observation group were significantly different. Conclusion：There was no significant difference in the efficacy of the two chemotherapy regimens,but the FAC chemotherapy regimen treatment of breast cancer patients with nausea,vomiting and gastrointestinal reactions are relatively large,while the TC group chemotherapy regimen bone pain is its unique adverse reactions,but the incidence is low. Symptomatic treatment can ease.