微血管性心绞痛中西医治疗的研究进展(综述)

Advances in the Chinese and western medicine treatment of coronary microvascular angina pectoris

心绞痛(AP)是冠心病最常见的一种临床表现类型。它的发生是由于心肌的需氧与冠状动脉的供氧失去平衡,致使心肌缺血缺氧所致。然而在临床工作中,10%~30%的心绞痛患者冠状动脉造影正常(冠状动脉管腔不规则或管腔狭窄程度<20%),在排除食管、胸、肺、肌肉、骨骼等非心源性胸痛与冠状动脉痉挛的基础上,确实存在典型劳力性心绞痛的症状与心肌缺血的证据,即微血管性心绞痛(MVA)。目前,多项研究显示:MVA与微血管内皮功能、血管结构以及血流动力学改变有着密切联系。虽然MVA患者的治疗及预后并非良好,但中西医在MVA方面也取得了一定进展。该文就MVA中西医治疗进展进行阐述。

Angina（AP） is the most common type of clinical manifestation of coronary heart disease. The loss of balance between myocardial oxygen and coronary artery supply causes myocardial ischemia and hypoxia. However,in clinical work,10%-30% of angina patients with normal coronary angiography（coronary artery lumen or the degree of stenosis 20%）,have labor angina and myocardial ischemia evidence excluding esophageal, thoracic,lung,muscle,bone and other non-cardiogenic chest pain and coronary artery spasm, that is,microvascular angina（MVA）.At present,a number of studies have shown that MVA and microvascular endothelial function, vascular structure and hemodynamic changes are closely linked. Although the treatment and prognosis of patients with MVA is not good, but the Chinese and Western medicine in the MVA has also made some progress. This article describes the progress of MVA in Chinese and western medicine treatment.