醒脑静对急性脑出血患者血浆FIB、DD、TNF-α水平的影响分析

Analysis of effects of Xingnaojing on plasma FIB,DD,and TNF-α levels of patients with acute cerebral hemorrhage

目的:观察醒脑静对急性脑出血患者血浆FIB、DD、TNF-α水平的影响。方法:选取88例急性脑出血患者为研究对象,以随机数字表法分成观察组和对照组各44例。对照组给予常规治疗,观察组在对照组的基础上给予醒脑静治疗。比较两组患者治疗前后血浆纤维蛋白原(Fibrinogen,FIB)、D-二聚体(D-Dimer,D-D)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)水平、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、格拉斯哥昏迷(Glasgow Coma Scale,GCS)评分及临床疗效等的差异。结果:观察组治疗后痊愈率为22.73%(10/44),总有效率为95.45%(42/44),均显著高于对照组的6.82%(3/44)和81.82%(36/44),差异有统计学意义(P<0.05);治疗后7 d与14 d,观察组NIHSS评分显著低于对照组,GCS评分均显著高于对照组,FIB显著高于对照组,DD及TNF-α值显著低于对照组,差异均有统计学意义(P<0.05)。结论:醒脑静治疗急性CH患者的疗效较常规治疗好,可显著改善患者预后。

Objective To study effects of Xingnaojing on plasma FIB, DD, and TNF-α of patients with acute cerebral hemorrhage. Methods： 88 cases of acute cerebral hemorrhage were selected as the research objects and divided into observation group （44cases） and control group （44 cases） according to the random number table method. The control group was given routine treatment,while the observation group was given Xingnaojing treatment based on that of the control group. The levels of plasma fibrinogen （FIB）,D-dimer （D-D）, tumor necrosis factor-α （TNF--α） before and after the treatment, the scores of national institute of health strokescale （NIHSS） and Glasgow coma score （GCS）, and the clinical curative effects of the two groups were compared. Results： After thetreatment, the cure rate and the total effective rate [22. 73% （10 / 44） and 95. 45% （42 / 44）] of the observation group were significantly higher than those of the control group [6. 82% （3 / 44） and 81. 82% （36 / 44）], and the differences were statistically significant （P〈0. 05）. 7d and 14d after the treatment, compared with those of the control group, the NIHSS score of the observation groupwas significantly lower, the GCS score was obviously higher, the FIB level was significantly higher, the levels of D-D and TNF-α wasobviously lower, and all the differences were statistically significant （P〈0. 05）. Conclusions： Xingnaojing in the treatment of the patients with acute cerebral hemorrhage is more effective than the routine treatment, and can significantly improve their prognosis.