C反应蛋白对老年髋部骨折患者术后1年死亡率及并发症的影响

Effect of C-reactive protein on postoperative 1-year mortality and complications in gerontal patients with hip fracture

目的:探析C反应蛋白(CRP)水平对老年髋部骨折患者术后1年死亡率及并发症的影响。方法:分析846例老年髋部骨折患者的临床资料,比较术后死亡组与生存组,并发症组与无并发症组的CRP水平。多因素Logistic回归分析CRP水平与老年髋部骨折患者术后1年死亡率及并发症发生率的关系。结果:死亡组患者的CRP水平明显高于生存组,且CRP<8 mg/L患者的死亡率明显低于8 mg/L≤CRP<40 mg/L患者与CRP≥40 mg/L患者(P<0.05)。并发症组与无并发症组的CRP水平比较差异无统计学意义,且CRP<8 mg/L患者、8 mg/L≤CRP<40 mg/L患者与CRP≥40 mg/L患者的并发症发生率均无明显统计学差异(P>0.05)。CRP水平与老年髋部骨折患者术后1年死亡率存在显著正相关性(P<0.01),但与术后1年并发症发生率无明显相关性(P>0.05)。结论:检测术前CRP水平可有效预测老年髋部骨折患者术后1年死亡率情况,CRP水平越高,死亡率则越高。

Objective： To analyze the effect of CRP on postoperative 1-year mortality and complications in gerontal patients with hip fractures. Methods： Clinical data of 846 gerontal patients with hip fracture were retrospectively analyzed. The levels of CRP in death group and survival group,the levels of CRP in complication group and non-complication group were compared. Multivariate logistic regression analysis was used to analyze the relationship between CRP level and postoperative 1-year mortality and complication rate in gerontal patients with hip fractures. Results： The CRP levels in death group were obviously higher than that in survival group,and the death rate in the patients with CRP 8 mg/L was obviously lower than that in the patients with 〈8 mg/L≤CRP 40 mg/L and CRP≥40 mg/L（ P〈0. 05）. The CRP levels in the complication group and non-complication group had no statistical difference,and the death rates in the patients with CRP 8 mg/L,8 mg/L≤CRP 〈40 mg/L and CRP≥40 mg/L had no statistical difference（ P〈0. 05）. There was a significant positive correlation between CRP levels and 1-year postoperative mortality in gerontal hip fractures（ P〈0. 01）,but there was no significant correlation with the incidence of complications after 1 year（ P〈0. 05）. Conclusion： The levels of CRP before the operation can effectively predict the 1-year postoperative mortality in the gerontal patients with fracture of hip. The higher the CRP levels,the higher the mortality rate.