右咪托咪定对食管癌和良性肺部肿瘤患者麻醉后的苏醒期指标、满意度及安全性影响关系

The effects of dextroimidine on resuscitation index,satisfaction and safety of patients with esophageal cancer and benign lung cancer

目的:分析右咪托咪定对食管癌和良性肺部肿瘤患者麻醉后的苏醒期指标、满意度及安全性影响关系。方法:选择78例需手术治疗的食管癌及良性肺部肿瘤患者,按双盲数字法分为对照组和观察组,每组各39例。所有患者均接受300 m L复方乳酸钠林格静脉注射。观察组患者静脉注射0.5μg/kg的右咪托咪定溶液;对照组患者相同体积的0.9%的生理盐水。记录患者在苏醒期的血流动力学、复苏期间的指标、躁动评分、苏醒时间及苏醒2 h后Ramsay评分;统计患者的满意度及不良反应发生率。结果:观察组患者的HR含量在T1~T3时,MBP在T0~T3时刻明显低于对照组,差异有统计学意义(P<0.05);观察组患者的躁动评分、苏醒时间、Ramsay评分明显优于对照组,差异有统计学意义(P<0.05)。两组患者在恢复自主呼吸时的时间及拔出器官导管的时间无明显差异,差异无统计学意义(P>0.05);观察组患者按指令睁眼的时间明显优于对照组,差异有统计学意义(P<0.05)。观察组患者的满意度、不良反应发生率明显优于对照组,差异具有统计学意义(P<0.05)。结论:右咪托咪定可应用于食管癌和肺部肿瘤手术患者的麻醉,能缩短患者的苏醒时间,提升患者Ramsay评分,降低心率且稳定血流动力学,使患者的苏醒期较为平稳,便于提高患者康复。

Objective： To analyze the relationship between the post-anesthesia resuscitation index,satisfaction and safety of dextroimidine in patients with esophageal cancer and benign lung cancer. Methods： 78 patients with esophageal cancer or benign lung cancer who underwent surgical treatment in our hospital from August 2015 to November 2016 were selected and divided into the control group and the observation group according to double blind digital method,ach with a total of 39 cases. All the patients were treated with300 ml compound sodium lactate injection. Patients in the observation group were given intravenous injection of 0. 5 μg/kg of the right midazolam solution,the control group of patients with the same volume of 0. 9% saline. Patients in hemodynamic recovery period,during the period of recovery index,resdessness score,recovery time and recovery after 2 h ramsay score,the incidence statistics of patient satisfaction and adverse reactions were recorded. Results： In the observation group,when the HR content was T1～ T3,the MBP at T0～ T3 time was significantly lower than that in the control group,the difference was not statistically significant（ P〈0. 05）. The restlessness score,recovery time and ramsay score in the observation group were significantly better than those in the control group,the difference was statistically significant（ P〈0. 05）. There was no significant difference between the two groups in the time of recovery of spontaneous respiration and the time of pulling out the organ catheter（ P〈0. 05）. The time of eye opening according to instruction in the observation group was significantly better than that in the control group（ P〈0. 05）. The incidence of patients＇ satisfaction and adverse reactions in the observation group was significantly better than that of the control group,and the difference was statistically significant（ P〈0. 05）. Conclusion： The Right midazolam can apply in patients with esophageal cancer or lung cancer,can shorten the recovery time of patients,improve patient ramsay score,reduce heart rate and stable hemodynamic,the patient＇s recovery period is relatively stable,so as to improve the rehabilitation of patients.