豁痰降逆方联合甲巯咪唑治疗Graves病临床观察

Effects of Phlegm-Ascending and Descending Recipe combined with Methimazole on Graves' Disease

目的:观察豁痰降逆方联合甲巯咪唑治疗甲状腺功能亢进症的临床效果。方法:选取100例甲状腺功能亢进症患者,用随机数字表分组,对照组给予甲巯咪唑治疗,观察组在对照组基础上加用豁痰降逆方治疗,比较两组临床疗效。结果:观察组治疗总有效率(94.00%)高于对照组(72.00%),差异有统计学意义(P<0.05);与治疗前相比较,两组治疗后甲状腺激素指标水平均不同程度改善,且观察组优于对照组,差异有统计学意义(P<0.05);与治疗前相比较,两组治疗后自身抗体指标水平均不同程度下降,且观察组指标水平明显低于对照组,差异有统计学意义(P<0.05);与治疗前相比较,两组治疗后脂联素和瘦素水平均不同程度改善,且观察组优于对照组,差异有统计学意义(P<0.05)。结论:豁痰降逆方联合甲巯咪唑治疗Graves病可显著减轻临床症状体征,改善甲状腺激素分泌,抑制自身抗体产生,并有助于调节脂联素及瘦素水平。

Objective To observe the clinical effect of Huatang Jiangni combined with methimazole in the treatment of hyperthyroidism. Methods 100 cases of hyperthyroidism were treated in Department of Endocrinology. Random number table was used to divide the patients. The control group was treated with methimasole. In the observation group, Jiangni treatment, compared the clinical efficacy of both groups. Results The total effective rate （94.00%） in observation group was higher than that in control group （72. 00% ）, the difference was statistically significant （ P 〈 0. 05 ） . Compared with those before treatment, the levels of thyroid hormone in both groups improved to different degrees after treatment, and the indexes in observation group were better than those in control group after treatment. The difference was statistically significant （ P 〈 0.05 ） . Compared with those before treatment, the levels of autoantibodies in both groups decreased to different degrees after treatment, and the indexes in the observation group were lower than those in the control group after treatment （ P 〈 0. 05） . Compared with those before treatment, the levels of adiponectin and leptin in both groups improved to some extent after treatment, and the indexes in the observation group were better than those in the control group after treatment. The difference was statistically significant （ P 〈 0. 05 ） . Conclusion Phlegm Jiangni decoction combined with methimazole treatment of Graves disease can significantly reduce the clinical signs, improve thyroid hormone secretion, inhibit the production of autoanti- bodies, and help regulate adiponeetin and leptin levels.