摘要
Photodynamic therapy plays an important role in cancer treatment.In this work,methylene blue(MB)-embedded calcium carbonate nanorods(CaCO_3-MB NRs)have been synthesized for p H-responsive photodynamic therapy and ultrasound imaging.The morphology of CaCO_3-MB NRs can be controlled by modulating the concentration of Na_2CO_3 aqueous solution.The generation of effective reactive oxygen species(ROS)were confirmed by 1,3-diphenylisobenzofuran(DPBF)probe.Both photodynamic therapy performance and echogenic performance of CaCO_3-MB NRs were investigated to confirm the feasibility of CaCO_3-MB nanohybrids for ultrasound image-guided photodynamic therapy.
Photodynamic therapy plays an important role in cancer treatment. In this work, methylene blue （MB）-embedded calcium carbonate nanorods （CaCO3-MB NRs） have been synthesized for pH-responsive photodynamic therapy and ultrasound imaging. The morphology of CaCO3-MB NRs can be controlled by modulating the concentration of Na2CO3 aqueous solution. The generation of effective reactive oxygen species （ROS） were confirmed by 1,3-diphenylisobenzofuran （DPBF） probe. Both photodynamic therapy performance and echogenic performance of CaCO3-MB NRs were investigated to confirm the feasibility of CaCO3-MB nanohybrids for ultrasound image-guided photodynamic therapy.
基金
supported by the National Key Research and Development Program of China (2017YFA0106100, 2016YFA0201501)
National Natural Science Foundation of China (51325304, 51373017, 51473014, 51521062, 51773013)
the Fundamental Research Funds for the Central Universities (BHYC1705A)
Higher Education and High-quality and World-class Universities (PY201603)
