细胞衰老与肿瘤进展

Cellular senescence and cancer progression

细胞衰老是细胞脱离细胞周期、丧失增殖能力后进入的一种相对稳定的状态，是抑制恶性肿瘤形成的重要机制。然而，越来越多的证据表明衰老细胞对周围的肿瘤微环境有负面影响，其中最重要的衰老相关性分泌表型（senescence—associated secretory phenotype，SASP）可以促进肿瘤进展及复发。虽然现在对SASP及其与肿瘤发生的关系所知有限，但其为肿瘤的治疗研究提供了更多新的思路。

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence show that senescent cells can have deleterious effects on the tissue microenvironment. The most significance of these effects is the acquisition of a senescence- associated secretory phenotype （SASP） that could promote tumor progression. Even with our currently limited knowledge of the SASP and its potential effects on carcinogenesis, promising new strategies for cancer therapies are oossible.