内脏脂肪指数与高尿酸血症发病关系的横断面研究

Relationship between the visceral adiposity index and hyperuricemia: a cross-sectional study

目的研究内脏脂肪指数(VAI)与高尿酸血症(HUA)发病风险的关系。方法选择2009年中国健康和营养状况调查(CHNS)的成人10 241例,剔除不符合纳入标准者,以7 864例(男性3 745例,女性4 119例)为对象进行横断面研究。根据有无HUA将研究对象分为男性、女性HUA组和非HUA组;根据VAI值的四分位将研究对象分为男性、女性第1、2、3、4四分位数组;比较其一般资料及心血管危险因素、代谢综合征组份水平,采用非条件Logistic回归分析不同VAI值者的HUA发病风险。结果对年龄、地理位置、教育水平、吸烟、饮酒、胆固醇、收缩压、舒张压、超敏C反应蛋白(hsCRP)、糖尿病等潜在混杂因素进行校正后,男性VAI的第2、3、4四分位数组相对于VAI的第1四分位数组,发生HUA的风险分别为1.665(1.217,2.278),2.514(1.865,3.390)和7.813(5.879,10.382);女性VAI的第2、3、4四分位数组相对于第1四分位数组,发生HUA的风险分别为1.645(0.828,3.270),3.235(1.724,6.070)和8.510(4.607,15.718)。结论 VAI为HUA的独立危险因素,能预测HUA的发生。

Objective To investigate the relationship between the visceral adiposity index（VAI） and risk of hyperuricemia（HUA）. Methods Selecting 10 241 adults from China Health and Nutrition Survey（CHNS） in 2009 and rejecting those who were not in conformity with the inclusion criteria,7 864 subjects（3 745 male,4 119 female） were served as the objects to carry out a cross-sectional study. According to with or without HUA,the male and female subjects were respectively divided into HUA group and no-HUA group. According to quartile grouping of VAI,the research objects were divided into 1^st,2^nd,3^rd and 4^th quantile group,for male and female,respectively. The general data,cardiovascular risk factors and the levels of metabolic syndrome components were compared. Logistic regression analysis was used to analyze the risk of HUA in patients with different VAI. Results After adjusting for age,geographical position,education level,smoking,drinking,cholesterol,systolic pressure,diastolic pressure,hypersensitive C-reactive protein（hs CRP）,diabetes and other potential confounder,the risks of HUA in 2^（nd）,3^（rd） and 4^（th） quantile group for males were 1. 665（1. 217,2. 278）,2. 514（1. 865,3. 390） and 7. 813（5. 879,10. 382） relative to 1^（st） quantile group,respectively,and the risk of HUA in 2^（nd）,3^（rd） and 4^（th） quantile group for females were 1. 645（0. 828,3. 270）,3. 235（1. 724,6. 070） and 8. 510（4. 607,15. 718）relative to 1^（st） quantile group,respectively. Conclusion VAI is an independent risk factor of HUA and can predict the occurrence of HUA.