宫颈癌与NFκB、PI3K/AKT信号通路的研究进展被引量：12

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摘要全世界范围内宫颈癌占女性癌症性疾病中的第2位,死亡率占第15位。由于筛查的普及和诊疗技术的提高,宫颈癌的死亡率大幅下降。目前较为公认的是人乳头瘤病毒(HPV)持续感染与宫颈癌发生密切相关,但其发病机制尚未明了,近期研究表明,3-磷酸肌醇激酶/丝氨酸苏氨酸蛋白激酶(PI3K/Akt)信号通路激活与宫颈癌耐药性相关,而核因子(NF)κB信号通路的上调与宫颈癌细胞的持续存续相关。本文复习近几年文献,重点对宫颈癌NFκB信号通路、PI3K/Akt信号通路及PI3K/Akt信号抑制剂的研究进展进行概述,以期为宫颈癌的发生机制和耐药性的解决办法提供线索。

作者张月涵张春梅潘云

机构地区大理大学基础医学院大理大学第一附属医院病理科

出处《中国临床研究》 CAS 2018年第4期565-567,570,共4页 Chinese Journal of Clinical Research

关键词宫颈癌耐药性 HPV PI3K/AKT 人乳头瘤病毒信号通路 NF

分类号 R737.33 [医药卫生—肿瘤]

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参考文献2

1赵玉婵,李莲,张连梅,刘晓兰.NF-κB、MMP-9在宫颈癌组织中的表达及意义[J].河北医药,2013,35(20):3050-3052. 被引量：4
2成莉,刘少扬,江大琼,龚玲玲.核转录因子κB在宫颈癌中的表达及其临床意义[J].武汉大学学报（医学版）,2005,26(2):231-234. 被引量：2

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