聚(L-丙交酯-co-ε-己内酯)电纺防粘连膜的研究

Study on the Electrospun Poly(L-Lactide-co-ε-Caprolactone) Membranes for Prevention of Adhesions

首次将聚(L-丙交酯-co-ε-己内酯)用于电纺防粘连膜的研究。通过对电纺条件的考查,发现在10k V电压、10%浓度、1m L/h注射速度下得到的电纺膜形貌最好,且纤维直径相对较细。聚(L-丙交酯-co-ε-己内酯)电纺膜尺寸稳定性良好,收缩率仅为2%。电纺膜拉伸强度约为4MPa,断裂伸长率约为300%。经过14周的体外降解,电纺膜吸水率达到25%左右,质量损失约为1.3%,特性黏度从3.5 d L/g下降到0.5 d L/g;然而电纺膜拉伸强度和断裂伸长率保持了近8周时间,在第10周之后降幅明显。负载替硝唑药物的电纺膜24h内释放了80%的药物,展现了"突释"的药物释放行为。

Poly（L-lactide-co-ε-caprolactone）（PLCA）was used to prepare the electrospun anti-adhesion membrane for the first time.Under the condition of 10 k V voltage,10% concentration and 1 m L/h flow rate,we obtained electrospun membrane with the best morphology and relatively small fiber diameter.The electrospun membrane displayed good dimensional stability with shrinkage of 2%.The PLCA membrane showed a tensile strength of 4 MPa,and a breaking elongation of 300%.After 14 weeks in vitro degradation in PBS buffer solution,the water absorption rate of the electrospun membrane reached 25%,the mass loss rate increased slightly to 1.3%,and the inherent viscosity decreased notably from 3.5 d L/g to 0.5 d L/g.The tensile strength and breaking elongation remained almost unchanged for 8 weeks,and then significantly declined after 10 weeks.The electrospun membrane loaded with tinidazole exhibited a ＂burst＂drug release profile,releasing80% of the drug within 24 hours.