间日疟原虫入侵红细胞的相关蛋白研究进展

Research progress on proteins associated with Plasmodium vivax invasion of erythrocytes

基于疟原虫入侵途径的多样化以及红细胞表面受体的多样性,间日疟原虫入侵红细胞的过程呈现高度的种特异性。寻找参与疟原虫入侵红细胞的相关分子,探索其入侵机制是疟疾研究领域的重点。间日疟原虫全基因组测序的完成,为从分子水平探索间日疟原虫的入侵机制和疟疾候选疫苗的研究提供了新的研究方法。本文通过达菲结合蛋白、网织红细胞结合蛋白、间日疟原虫色氨酸富集抗原等几种重要的入侵蛋白,对间日疟原虫入侵红细胞分子机制的研究进展作一综述。

Different Plasmodium species utilize different invasion pathways and specific sets of ligand-receptor interactions to exert distinct invasion behaviors of merozoites. Most studies on host cell invasion by Plasmodium have concentrated on invasion of erythrocytes. With completion of the whole-genome sequencing of P.vivax, proteins involved in erythrocyte invasion, such as the duffy binding protein, the reticulocyte binding protein,and tryptophan-rich antigens, have been identified. This review summarizes the role of these proteins in erythrocyte invasion.