寄生虫14-3-3蛋白的研究进展

Research development on 14-3-3 protein in parasites

14-3-3蛋白在寄生虫的生长发育和环境适应中起重要作用。近年来研究表明,该蛋白可以和许多信号蛋白(包括磷酸酶、激酶和一些跨膜受体等)结合,从而广泛参与调节,如信号转导、新陈代谢、细胞生长、细胞增殖分化、细胞凋亡、细胞周期调控等多种重要细胞生命活动。在寄生虫领域对其进行系统性研究,有助于理解其参与寄生虫生长发育的生物学功能及调控机制。本文从寄生虫14-3-3蛋白的基因鉴定、结构特征、生物学功能和应用前景等方面进行了综述。

The 14-3-3 protein plays an important role in parasite development and environmental adaptation.Recent studies have shown that the 14-3-3 protein can bind to a plethora of interacting signaling proteins including phosphatases, kinases and some transmembrane receptors, thus participating in a wide range of important regulatory processes, such as signal transduction, metabolism, cell growth, cell proliferation and differentiation, apoptotic cell death, and cell cycle control. Systematic studies on the 14-3-3 protein can advance our understanding of the biological functions and regulatory mechanisms of parasite growth and development. This review summarizes the gene iden-tification, structure, biological functions and application potentials of the 14-3-3 protein in parasites.