阴道微生态失调与不孕症相关性的系统评价

System assessment of the correlation between vaginal microecological balance disorders and infertility

目的系统评价阴道微生态失调与不孕症的相关性。方法采用Cochrane系统评价方法，检索MEDLINE、EMBASE和SinoMed数据库，检索时限为建库至2017年10月，并手工检索相关参考文献，纳人研究阴道微生态失调与不孕症相关性的队列研究、病例对照研究和横断面研究。应用RevMan5．3软件进行Meta分析。结果检索到文献1724篇，纳入9个横断面研究，不孕症患者1702例，对照1665例。Meta分析结果提示，不孕症患者的阴道微生态失调发生率高于对照组[OR=3．15，95％CI（1．57，6．32），P=0．001]。结论尽管现有证据表明阴道微生态失调与不孕症的发生具有相关性，但需进一步开展高质量病例对照研究或队列研究以验证此结论。

Objective To evaluate the association of vaginal dysbiosis and infertility. Methods Cohort studies, ease-control studies and cross-sectional studies were searched in electronic databases, including MEDLINE, EMBASE and SinoMed （from inception to October 2017） ; in addition, the reference lists of included studies and similar reviews were handsearched. These studies investigating the correlation between vaginal dysbiosis and infertility were included. The Meta-Analysis was performed by RevMan 5.3 software. Results 1 724 records were retrieved by the search; from those, 9 cross-sectional studies were included, comprising 3 367 participants （1 702 in infertility group and 1 665 in control group ）. The likelihood of vaginal dysbiosis in infertility group is higher than that of control group [ OR = 3.15, 95% C1 （1.57, 6. 32）, P = 0. 001 1. Conclusions The available evidence suggests that vaginal dysbiosis was associated with the incidence of infertility. However, further case-control studies or cohort studies are required to confirm or refute these findings.