摘要
免疫检测点阻断疗法等肿瘤免疫疗法近年在临床上取得了重大突破,但仍存在响应率低等显著缺点,需开发新的肿瘤免疫疗法以使更多肿瘤患者受益。胆固醇作为细胞质膜脂质的重要组成成分,其代谢可以影响T细胞的质膜环境及效应功能。本研究发现,通过调控胆固醇代谢可以增强CD8^+T细胞的抗肿瘤免疫反应。抑制关键胆固醇酯化酶ACAT1的活性,CD8^+T细胞质膜游离胆固醇水平上调,细胞的抗肿瘤免疫应答显著增强,这为肿瘤免疫治疗提供了新思路和新方法。
Immune checkpoint blockade and other cancer immunotherapies have achieved great success in clinic but problems such as low response rate still remain. Cholesterol is a key component of cell membrane, whose cellular metabolism can influence the plasma membrane environment and effector function of T cells. We have found that the anti-tumor immune response of CD8+T cells can be potentiated by modulating cellular cholesterol metabolism. Inhibiting the activity of ACAT1, a key cholesterol esterification enzyme, can upregulate the cholesterol level on CD8+T cell plasma membrane, and significantly enhance the anti-tumor effector function. This finding provides a new method for cancer immunotherapy.
作者
白轶冰
许琛琦
BAI Yibing;XU Chenqi(Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China)
出处
《科技导报》
CAS
CSCD
北大核心
2018年第7期33-36,共4页
Science & Technology Review
基金
国家自然科学基金项目(31425009,31621003)